Chromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae).

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorFonseca, Juliane Morais da-
Autor(es): dc.creatorReis, Adriana Cotta Cardoso-
Autor(es): dc.creatorPereira, Guilherme Rocha-
Autor(es): dc.creatorMoura, Hélia Maria Marques de-
Autor(es): dc.creatorSouza Filho, José Dias de-
Autor(es): dc.creatorSilva, Breno de Mello-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Data de aceite: dc.date.accessioned2025-08-21T15:17:24Z-
Data de disponibilização: dc.date.available2025-08-21T15:17:24Z-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17551-
Fonte completa do material: dc.identifierhttps://doi.org/10.1590/s2175-97902022e18802-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1009322-
Descrição: dc.descriptionThe flavonoids and xanthones present in the ethanol extracts of leaves and stems of Fridericia samydoides showed that anti-dengue activities in vitro were investigated qualitatively by liquid chromatography–ultraviolet-mass spectrometry in series. Nineteen flavones and fifteen xanthones were detected and characterized on the basis of their fragmentation pattern in the positive and negative ion mode tandem mass spectrometry spectra and ultraviolet bands. Acacetin, chrysin, vitexin, isovitexin, orientin, isoorientin, mangiferin, 2’-O-trans-caffeoylmangiferin, 2’-O-trans-coumaroylmangiferin and 2’-O-trans-cinnamoylmangiferin were identified by comparison with authentic samples. The other compounds detected were tentatively assigned by analysis of the spectral data and by comparison with literature reports. In addition, it performed the fractionation of the leaves extract leading to the isolation of mangiferin, isovitexin and isoorientin. All extracts and isolated compounds inhibited the Dengue virus replication cycle with EC50 less than 25.0 μg/mL for extracts and 272.5, 85.6 and 79.3 μg/mL for mangiferin, isovitexin and isoorientin, respectively.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectAntiviral activity-
Palavras-chave: dc.subjectC-glycosyxanthone-
Palavras-chave: dc.subjectDengue type 2-
Título: dc.titleChromatographic profile of xanthones and flavonoids in the anti-dengue extracts of Fridericia samydoides (Cham.) L.G. Lohmann (Bignoniaceae).-
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