Assessment of the biological potential of diaryltriazene-derived triazene compounds.

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Autor(es): dc.creatorFigueirêdo, Patricia de Maria Silva-
Autor(es): dc.creatorSampaio Filho, José Costa-
Autor(es): dc.creatorSodré, Alzirene de Jesus Sales-
Autor(es): dc.creatorCastro Júnior, José Ribamar de-
Autor(es): dc.creatorGonçalves, Ingrid Santos-
Autor(es): dc.creatorBlasques, Rodrigo Vieira-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorLima, Benedicto Augusto Vieira-
Autor(es): dc.creatorMarques, Larissa dos Anjos-
Autor(es): dc.creatorCoutinho, Denise Fernandes-
Autor(es): dc.creatorSantos, Ana Paula Silva de Azevedo dos-
Autor(es): dc.creatorLuz, Tássio Rômulo Silva Araújo-
Autor(es): dc.creatorMiranda, Rita de Cassia Mendonça de-
Autor(es): dc.creatorSantos, Julliana Ribeiro Alves dos-
Autor(es): dc.creatorDoriguetto, Antônio Carlos-
Autor(es): dc.creatorPividori, María Isabel-
Autor(es): dc.creatorHörner, Manfredo-
Autor(es): dc.creatorVillis, Paulo Cesar Mendes-
Data de aceite: dc.date.accessioned2025-08-21T15:17:23Z-
Data de disponibilização: dc.date.available2025-08-21T15:17:23Z-
Data de envio: dc.date.issued2021-12-20-
Data de envio: dc.date.issued2021-12-20-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14278-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-021-81823-2-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1009311-
Descrição: dc.descriptionIn the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X= 2 and 5; Y= 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the efective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the frst to report promising activities of triazene compounds against yeast and flamentous fungi. The results showed the potential utility of triazenes as agents afecting selected resistant bacterial and fungal strains.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: o PDF do artigo.-
Título: dc.titleAssessment of the biological potential of diaryltriazene-derived triazene compounds.-
Aparece nas coleções:Repositório Institucional - UFOP

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