Insights into CX3CL1/fractalkine during experimental Trypanosoma cruzi infection.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMenezes, Tatiana Prata-
Autor(es): dc.creatorMachado, Bianca Alves Almeida-
Autor(es): dc.creatorToledo, Débora Nonato Miranda de-
Autor(es): dc.creatorSantos, Priscilla Vilela dos-
Autor(es): dc.creatorRibeiro, Laís-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Data de aceite: dc.date.accessioned2025-08-21T15:16:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:16:46Z-
Data de envio: dc.date.issued2023-03-21-
Data de envio: dc.date.issued2023-03-21-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16398-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.parint.2021.102530-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1008976-
Descrição: dc.descriptionTrypanosoma cruzi triggers a progressive myocarditis in mammalians through activation and recruitment of leukocytes and release of inflammatory mediators. The chemokine CX3CL1 has been highlighted for its potential role in the parasite controlling in end-pathological status of infected hosts. This study investigated the systemic and cardiac release of CX3CL1 in experimental T. cruzi infection and how this chemokine correlates with endothelin-1 and TNF. Male Fisher rats (n = 20) were infected, or not, by the Y strain of T. cruzi and parasitemia was daily evaluated and immunoassays performed in the cardiac tissue macerated supernatant and in serum to evaluate CX3CL1, endothelin, and TNF production on days 5 and 15 of infection. T. cruzi infection induced a higher serum and cardiac production of these mediators on days 5 and 15 of infection. In both periods of infection, respectively, CX3CL1 showed a positive correlation with TNF (r = 0.833, p < 0.001 and r = 0.723, p < 0.001) and endothelin-1 (r = 0.801, p < 0.05 and r = 0.857, p < 0.001), which reinforce its participation in the T. cruzi-induced myocarditis development.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMyocarditis-
Palavras-chave: dc.subjectEndothelin-1-
Título: dc.titleInsights into CX3CL1/fractalkine during experimental Trypanosoma cruzi infection.-
Aparece nas coleções:Repositório Institucional - UFOP

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