Intranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice.

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Autor(es): dc.creatorFróes, Sophia Dias Pozzolini-
Autor(es): dc.creatorSouza, Ana Beatriz Farias de-
Autor(es): dc.creatorMatos, Natália Alves de-
Autor(es): dc.creatorPhilips, Nicole Elizabeth-
Autor(es): dc.creatorCosta, Guilherme de Paula-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorCangussú, Silvia Dantas-
Autor(es): dc.creatorBezerra, Frank Silva-
Data de aceite: dc.date.accessioned2025-08-21T15:16:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:16:22Z-
Data de envio: dc.date.issued2020-03-10-
Data de envio: dc.date.issued2020-03-10-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11973-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1569904819300667?via%3Dihub-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.resp.2019.04.013-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1008720-
Descrição: dc.descriptionBronchial obstruction, caused by retained secretions, is often treated by the administration of mucoactive agentes including distilled water, saline, hypertonic saline, and sodium bicarbonate. However, the inflammatory effect of these solutions on the lungs remains unclear. This study evaluated the instillation effects of different solutions on oxidative stress and lung inflammatory response in C57BL/6 mice. Fifty C57BL/6 mice were divided into 5 groups: control (CG); distilled water (DWG), hypertonic saline (HSG), saline (SG) and sodium bicarbonate (SBG). CG was exposed to ambient air while DWG, HSG, SG and SBG had 50 μl of respective solutions administered intranasally for 5 consecutive days. Twenty-four hours after the last intranasal instillation, all animals were euthanized for subsequent analysis. All solutions promoted increased recruitment of inflammatory cells to the lung compared to controls. Superoxide dismutase activity was lower in HSG compared to all other groups; catalase activity was reduced in SG, while it increased in SBG and DWG compared to CG. Finally, there was na increase in the inflammatory markers TNF-α, CCL2 and IFN-γ in DWG compared to CG, SG and HSG. In conclusions, the intranasal instillation of different solutions promotes redox imbalance and inflammation on lungs of adult mice.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleIntranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice.-
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