Identification, characterization and quantification of xanthones from Fridericia formosa leaves extract with antiviral activity.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorVaz, Luana Beatriz Araújo-
Autor(es): dc.creatorAmparo, Tatiane Roquete-
Autor(es): dc.creatorReis, Adriana Cotta Cardoso-
Autor(es): dc.creatorSilva, Breno de Mello-
Autor(es): dc.creatorMagalhães, Cíntia Lopes de Brito-
Autor(es): dc.creatorKohlhoff, Markus-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Data de aceite: dc.date.accessioned2025-08-21T15:15:44Z-
Data de disponibilização: dc.date.available2025-08-21T15:15:44Z-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19657-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-024-51881-3-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1008351-
Descrição: dc.descriptionFridericia formosa (Bureau) L.G. Lohmann (Bignonaceae) is a neotropical liana species found in the Cerrado biome in Brazil. It has been of great interest to the scientific community due to its potential as a source of new antivirals, including xanthones derived from mangiferin. In this context, the present study aimed to characterize and quantify the xanthones present in the ethanol extract of this species using high performance liquid chromatography. Additionally, the antiviral activity against Chikungunya, Zika, and Mayaro viruses was evaluated. The chromatographic analyses partially identified twenty-six xanthones, among which only fourteen had already been described in the literature. The xanthones mangiferin, 2′-O-trans-caffeoylmangiferin, and 2′-O-transcoumaroylmangiferin, are present in higher quantities in the extract, at concentrations of 9.65%, 10.68%, and 3.41% w/w, respectively. In antiviral assays, the extract inhibited the multiplication cycle only for the Mayaro virus with a CE50 of 36.1 μg/mL. Among the isolated xanthones, 2′-O-transcoumaroylmangiferin and 2′-O-trans-cinnamoylmangiferin inhibited the viral cytopathic effect with CE50 values of 180.6 and 149.4 μg/mL, respectively. Therefore, the extract from F. formosa leaves, which has a high content of xanthones, has antiviral potential and can be a source of new mangiferin derivatives.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: PDF do artigo.-
Título: dc.titleIdentification, characterization and quantification of xanthones from Fridericia formosa leaves extract with antiviral activity.-
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