Cytotoxicity, anti-poliovirus activity and in silico biological evaluation of constituents from Maytenus gonoclada (Celastraceae).

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Mauro Lúcio Gonçalves de-
Autor(es): dc.creatorAssenço, Regina Aparecida Gomes-
Autor(es): dc.creatorSilva, Grácia Divina de Fátima-
Autor(es): dc.creatorLopes, Júlio César Dias-
Autor(es): dc.creatorSilva, Fernando César-
Autor(es): dc.creatorLanna, Maria Célia da Silva-
Autor(es): dc.creatorMagalhães, José Carlos de-
Autor(es): dc.creatorDuarte, Lucienir Pains-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Data de aceite: dc.date.accessioned2025-08-21T15:15:17Z-
Data de disponibilização: dc.date.available2025-08-21T15:15:17Z-
Data de envio: dc.date.issued2017-07-06-
Data de envio: dc.date.issued2017-07-06-
Data de envio: dc.date.issued2014-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8189-
Fonte completa do material: dc.identifierhttps://innovareacademics.in/journals/index.php/ijpps/article/view/2553-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1008060-
Descrição: dc.descriptionObjective: The in silico free access web tools PASS online and ChemMapper were used to predict potential biological activities of compounds 1 to 8 isolated from Maytenus gonoclada (Celastraceae). The constituents 4’-O-methylepigalocatequin (6), tingenone (7) and proanthocyanidin A (8), and ethanolic extracts were subjected to in vitro cytotoxicity using VERO cells and anti-Poliovirus assays. Methods: QSAR and molecular superposition, correlating the average number of pharmacophores were used in the prediction studies. Cellular line VERO ATCC CCL-81 was used to determine anti-Poliovirus effect, observed by colorimetric (MTT) method. The annexing V/propidium iodide assay was used to determine the occurrence of apoptosis in the cytotoxicity assays. Results: The experimental results found for constituents 6-8 were in accordance with observed data obtained through PASS online and ChemMapper simulation. Conclusion: Compound 7 showed higher cytotoxic and apoptosis induction properties, and 6 and 8 presented anti-Poliovirus activity.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectVERO cells Cytotoxicity-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectChemMapper-
Palavras-chave: dc.subjectPASS online-
Título: dc.titleCytotoxicity, anti-poliovirus activity and in silico biological evaluation of constituents from Maytenus gonoclada (Celastraceae).-
Aparece nas coleções:Repositório Institucional - UFOP

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