Biodistribution of long-circulating PEG-Grafted nanocapsules in mice : effects of PEG chain length and density.

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Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Autor(es): dc.creatorLegrand, Philippe-
Autor(es): dc.creatorMorgat, Jean-Louis-
Autor(es): dc.creatorVert, Michel-
Autor(es): dc.creatorMysiakine, Evgueni-
Autor(es): dc.creatorGref, Ruxandra-
Autor(es): dc.creatorDevissaguet, Jean-Philippe-
Autor(es): dc.creatorBarratt, Gillian-
Data de aceite: dc.date.accessioned2025-08-21T15:14:45Z-
Data de disponibilização: dc.date.available2025-08-21T15:14:45Z-
Data de envio: dc.date.issued2017-03-31-
Data de envio: dc.date.issued2017-03-31-
Data de envio: dc.date.issued2001-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7512-
Fonte completa do material: dc.identifierhttp://link.springer.com/article/10.1023/A:1012248721523-
Fonte completa do material: dc.identifierhttps://doi.org/10.1023/A:1012248721523-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1007742-
Descrição: dc.descriptionPurpose: To study the pharmacokinetics and biodistribution of novel polyethyleneglycol (PEG) surface-modified poly(rac-lactide) (PLA) nanocapsules (NCs) and to investigate the influence of PEG chain length and content. Methods: The biodistribution and plasma clearance in mice of different NC formulations were studied with [3H]-PLA. PLA-PEG copolymers were used in NC preparations at different chain lengths (5 kDa and 20 kDa) and PEG contents (10% and 30% w/w of total polymer). In vitro and in vivo stability were also checked. Results: Limited [3H]-PLA degradation was observed after incubation in mouse plasma for 1 h, probably because of to the large surface area and thin polymer wall. After injection into mice, NCs prepared with PLA-PEG copolymers showed an altered distribution compared to poloxamer-coated PLA NCs. An increased concentration in plasma was also observed for PLA-PEG NCs, even after 24 h. A dramatic difference in the pharmacokinetic parameters of PLA-PEG 45–20 30% NCs compared to poloxamer-coated NCs indicates that covalent attachment, longer PEG chain lengths, and higher densities are necessary to produce an increased half-life of NCs in vivo. Conclusions: Covalently attached PEG on the surface of NCs substantially can reduce their clearance from the blood compartment and alter their biodistribution.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPlasma stability-
Palavras-chave: dc.subjectPlasma clearance-
Título: dc.titleBiodistribution of long-circulating PEG-Grafted nanocapsules in mice : effects of PEG chain length and density.-
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