Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres.

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Autor(es): dc.creatorLana, Gwenaelle Elza Nathalie Pound-
Autor(es): dc.creatorGarcia, Giani Martins-
Autor(es): dc.creatorTrindade, Izabel Cristina-
Autor(es): dc.creatorOliveira, Patricia Capelari de-
Autor(es): dc.creatorPontífice, Thaís Godinho-
Autor(es): dc.creatorVilela, José Mário Carneiro-
Autor(es): dc.creatorAndrade, Margareth Spangler-
Autor(es): dc.creatorNottelet, Benjamin-
Autor(es): dc.creatorPostacchini, Bruna Bueno-
Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Data de aceite: dc.date.accessioned2025-08-21T15:13:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:13:38Z-
Data de envio: dc.date.issued2019-04-22-
Data de envio: dc.date.issued2019-04-22-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11080-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0928493118307690-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1006973-
Descrição: dc.descriptionFor best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of π-π interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectDrug nanocarrier-
Palavras-chave: dc.subjectBiodegradable polymer-
Palavras-chave: dc.subjectAmphiphilic block copolym-
Palavras-chave: dc.subjectField flow fractionation-
Título: dc.titlePhthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres.-
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