Yeast genes YOL002C and Sul1 are involved in neomycine resistance.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCastro, Ieso de Miranda-
Autor(es): dc.creatorCabral, Daniela Bastos-
Autor(es): dc.creatorTrópia, Maria José Magalhães-
Autor(es): dc.creatorBarnabé, Fabiana Maria de Almeida-
Autor(es): dc.creatorBrandão, Rogélio Lopes-
Data de aceite: dc.date.accessioned2025-08-21T15:13:06Z-
Data de disponibilização: dc.date.available2025-08-21T15:13:06Z-
Data de envio: dc.date.issued2017-03-20-
Data de envio: dc.date.issued2017-03-20-
Data de envio: dc.date.issued2001-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7393-
Fonte completa do material: dc.identifierhttp://link.springer.com/article/10.1023/A:1016707627056-
Fonte completa do material: dc.identifierhttps://doi.org/10.1023/A:1016707627056-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1006474-
Descrição: dc.descriptionIn previous studies we suggested the importance of the control of plasma membrane H+-ATPase by a phosphatidylinositol-like pathway for cellular proton extrusion in Saccharomyces cerevisiae (Brandão et al. 1994; Coccetti et al. 1998). The observations that provided the model above include the inhibition of the glucose-induced activation of the plasma membrane H+-ATPase as well as the inhibition of the glucose-induced external acidification by neomycin, a known inhibitor of the phosphatidylinositol turnover in eukaryotic cells. In this work, using two libraries, we isolated two yeast clones that were able to prevent the inhibition of glucose-induced activation of the H+-ATPase by neomycin. We show that the YOL002C gene, which encodes a protein of unknown function, and the SUL1 gene, which is a sulphate transporter belonging to the major facilitator superfamily, suppress growth inhibition by neomycin. However, they are not required for glucose-induced activation of the plasma membrane H+-ATPase. The resistance of the clones to neomycin is probably related to the level and/or activity of proteins functioning as drug extrusion pumps.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectGrowth inhibition-
Título: dc.titleYeast genes YOL002C and Sul1 are involved in neomycine resistance.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.