Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorTeixeira, Tamara-
Autor(es): dc.creatorRibeiro, Gabriel Henrique-
Autor(es): dc.creatorGonçalves, Guilherme R.-
Autor(es): dc.creatorHonorato, João-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Data de aceite: dc.date.accessioned2025-08-21T15:12:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:12:22Z-
Data de envio: dc.date.issued2025-02-25-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19793-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0020169324001683-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.ica.2024.122078-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1005794-
Descrição: dc.descriptionNew ruthenium(II) complexes bearing benzoate (AB) ligand with the general formula [Ru(AB)(bipy)(P–P)]PF6, where 2,2′-bipyridine (bipy) and different diphosphine ligands, (P–P) = 1,2′-bis(diphenylphosphine)ethane (dppe, 1), 1,3′-bis(diphenylphosphine)propane (dppp, 2) and 1,2′-bis(diphenylphosphine)ferrocene (dppf, 3), were synthesized. The compounds were characterized by molar conductivity, elemental analysis, cyclic vol- tammetry, infrared and UV–Vis spectroscopies, NMR, and by single-crystal X-ray diffraction for complexes 1 and 2. The complexes showed a weak interaction to CT-DNA through DNA minor groove, with Kb values at around 103 -104 M− 1 . CT-DNA interaction assays by viscosity and circular dichroism (CD) suggested that the compounds do not significantly alter the secondary DNA structure. The complexes are cytotoxic against MDA-MB-231, MCF- 7 (breast) and A549 (lung) tumor cell lines, with IC50 values in the range of 1 to 17 μM. The compounds 1-3 showed high selectivity against triple-negative breast tumor cells. Remarkably, complexes 1 and 3 show greater cytotoxic activity against cells than cisplatin, being promising agents for tumor treatment.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectRuthenium-
Palavras-chave: dc.subjectDiphosphines-
Palavras-chave: dc.subjectBipyridine-
Palavras-chave: dc.subjectBenzoate-
Palavras-chave: dc.subjectDNA-
Título: dc.titleSelective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA.-
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