Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCoelho, Daniel Barbosa-
Autor(es): dc.creatorPimenta, Eduardo Mendonça-
Autor(es): dc.creatorCruz, Izinara Rosse da-
Autor(es): dc.creatorVeneroso, Christiano Eduardo-
Autor(es): dc.creatorPussieldi, Guilherme de Azambuja-
Autor(es): dc.creatorOliveira, Lenice Kappes Becker-
Autor(es): dc.creatorOliveira, Emerson Cruz de-
Autor(es): dc.creatorCarvalho, Maria Raquel Santos-
Autor(es): dc.creatorGarcia, Emerson Silami-
Data de aceite: dc.date.accessioned2025-08-21T15:12:11Z-
Data de disponibilização: dc.date.available2025-08-21T15:12:11Z-
Data de envio: dc.date.issued2019-04-25-
Data de envio: dc.date.issued2019-04-25-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11129-
Fonte completa do material: dc.identifierhttps://journals.lww.com/nsca-jscr/Abstract/publishahead/Alpha_Actinin_3_R577X_Polymorphism_Influences.95358.aspx#print-article-link-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1005627-
Descrição: dc.descriptionThe purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/ RX (p , 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/ RX group (p , 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p , 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athletes-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectACTN3-
Palavras-chave: dc.subjectPhysiological stress-
Palavras-chave: dc.subjectPerformance-
Palavras-chave: dc.subjectMuscle microtrauma-
Palavras-chave: dc.subjectBlood markers-
Título: dc.titleAlpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game.-
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