The deleterious impact of exposure to different inhaled anesthetics is time dependent.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMachado Júnior, Pedro Alves-
Autor(es): dc.creatorSouza, Ana Beatriz Farias de-
Autor(es): dc.creatorCastro, Thalles de Freitas-
Autor(es): dc.creatorPerucci, Luiza Oliveira-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorCangussú, Silvia Dantas-
Autor(es): dc.creatorBezerra, Frank Silva-
Data de aceite: dc.date.accessioned2025-08-21T15:11:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:11:57Z-
Data de envio: dc.date.issued2023-10-26-
Data de envio: dc.date.issued2023-10-26-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17679-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0024320522007044?via%3Dihub-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.lfs.2022.121004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1005450-
Descrição: dc.descriptionIn this study, the effects of exposure to isoflurane, sevoflurane and desflurane on the oxidative response and inflammation at different times was analyzed in the lungs of adult C57BL/6 mice. 120 animals were divided into 3 groups (n = 40): Isoflurane (ISO), Sevoflurane (SEV) and Desflurane (DES) and exposed to these anesthetics for 1 h (n = 10), 2 h (n = 10) and 3 h (n = 10), at a minimum alveolar concentration (MAC) equal to 1. The control group (CG) (n = 10) was exposed to ambient air. 24 h after the experimental protocol, the animals were euthanized and the bronchoalveolar lavage fluid (BALF), blood and lung tissue samples were collected. In the BALF, animals exposed to isoflurane for 2 h and 3 h showed a greater influx of leukocytes, especially macro- phages compared to the CG. The ISO3h had lower leukocyte counts in the peripheral blood compared to CG, ISO1h and ISO2h. There was an increase in CCL-2 levels in the ISO3h compared to the CG. Superoxide dismutase activity was higher in ISO1h compared to CG. The activity of catalase was higher in the ISO1h and ISO2h compared to the CG. The lipid peroxidation, as well as carbonylated protein were higher in the ISO3h compared to the CG (p < 0.05). Similar results were observed in the exposure of SEV and DES compared to inflammation and redox imbalance in different periods. This study demonstrated that time is a determinant to promote a local and systemic inflammatory response to different inhalational anesthetics in a healthy murine model.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectInhalational anesthetics-
Palavras-chave: dc.subjectLung inflammation-
Palavras-chave: dc.subjectRedox imbalance-
Palavras-chave: dc.subjectMice-
Título: dc.titleThe deleterious impact of exposure to different inhaled anesthetics is time dependent.-
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