Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Lucas Martins-
Autor(es): dc.creatorSiqueira, Fallon dos Santos-
Autor(es): dc.creatorSilva, Michelle T.-
Autor(es): dc.creatorMachado, José Vaz Cardoso-
Autor(es): dc.creatorCordeiro, Cleydson Finotti-
Autor(es): dc.creatorDiniz, Lívia de Figueiredo-
Autor(es): dc.creatorCampos, Marli Matiko Anraku de-
Autor(es): dc.creatorFranco, Lucas Lopardi-
Autor(es): dc.creatorSouza, Thiago Belarmino de-
Autor(es): dc.creatorHawkes, Jamie Anthony-
Autor(es): dc.creatorCarvalho, Diogo Teixeira-
Data de aceite: dc.date.accessioned2025-08-21T15:11:23Z-
Data de disponibilização: dc.date.available2025-08-21T15:11:23Z-
Data de envio: dc.date.issued2023-10-17-
Data de envio: dc.date.issued2023-10-17-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17599-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s12223-023-01057-9-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s12223-023-01057-9-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1004983-
Descrição: dc.descriptionIn the constant search for new pharmacological compounds, molecular hybridisation is a well-known technique whereby two or more known pharmacophoric subunits are combined to create a new “hybrid” compound. This hybrid is expected to maintain the characteristics of the original compounds whilst demonstrating improvements to their pharmacological action. Accordingly, we report here a series of molecular hybrid compounds based upon eugenol and chloramphenicol pharmacophores. The hybrid compounds were screened for their in vitro antimicrobial potential against Gram-negative and Gram-positive bacteria and also rapidly growing mycobacteria (RGM). The results highlight that the antimicrobial profiles of the hybrid compounds improve in a very clear fashion when moving through the series. The most prominent results were found when comparing the activity of the hybrid compounds against some of the multidrug-resistant clinical isolates of Pseudomonas aeruginosa, methicillin-resistant clinical isolates of Staphylococcus aureus (MRSA) and clinical isolates of rapidly growing mycobacteria.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectHybridisation-
Palavras-chave: dc.subjectRapidly growing mycobacteria-
Título: dc.titleSynthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores.-
Aparece nas coleções:Repositório Institucional - UFOP

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