Spectroscopic investigation of organotin (IV) derivatives of 7-epiclusianone : a preliminary in vitro antitumor evaluation of HN-5 human carcinoma cell.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorVieira, Flaviana Tavares-
Autor(es): dc.creatorMaia, José Roberto da Silveira-
Autor(es): dc.creatorVilela, Marcelo José-
Autor(es): dc.creatorArdisson, José Domingos-
Autor(es): dc.creatorSantos, Marcelo Henrique dos-
Autor(es): dc.creatorOliveira, Tânia Toledo de-
Autor(es): dc.creatorNagem, Tanus Jorge-
Data de aceite: dc.date.accessioned2025-08-21T15:11:14Z-
Data de disponibilização: dc.date.available2025-08-21T15:11:14Z-
Data de envio: dc.date.issued2017-06-19-
Data de envio: dc.date.issued2017-06-19-
Data de envio: dc.date.issued2009-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7981-
Fonte completa do material: dc.identifierhttps://www.degruyter.com/view/j/mgmc.2009.32.5/mgmc.2009.32.5.235/mgmc.2009.32.5.235.xml-
Fonte completa do material: dc.identifierhttps://doi.org/10.1515/MGMC.2009.32.5.235-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1004878-
Descrição: dc.descriptionA series of organotin(IV) compounds have been prepared by reaction with 7-epiclusianone (Epi), a natural product extracted from fruits of Rheedia gardneriana. This compound has an interesting motif with several coordinating sites for metal-ligand bond formation, and in solution, it shows a keto-enol tautomerism. The NMR of the organotin(IV) derivatives has revealed intramolecular hydrogen bonding, indicating that the keto-enol tautomerism of 7-epiclusianone is not involved upon coordination of those, but the absence of this bonding type in the case of the SnCl4 derivative suggests a strong interaction. The Mössbauer spectroscopy has revealed five- and six-fold coordination for the organotin(IV) and SnCL» derivatives in the solid state. However, in solution all tin complexes have six-fold coordination, as shown by "9Sn NMR. The overall data point out that the organotin(IV) precursors SnClxPri4_x (x = 1, 2) are weakly bonded to the 7- epiclusianone, except the SnC^. Bioassay in vitro of the substance test [SnClPh3(£/7/)] (1) has been investigated using two epithelial cells: normal MDCK from canine kidney, and IIN-5 from a human carcinoma of the tongue. The results clearly demonstrate that the time for cellular reproduction has been reduced in the presence of the substance test.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subject7-epiclusianone-
Palavras-chave: dc.subjectOrganotin-
Palavras-chave: dc.subjectCarcinoma-
Palavras-chave: dc.subjectSpectroscopy-
Título: dc.titleSpectroscopic investigation of organotin (IV) derivatives of 7-epiclusianone : a preliminary in vitro antitumor evaluation of HN-5 human carcinoma cell.-
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