Reduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza, Ana Carolina Moreira-
Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Autor(es): dc.creatorSilveira, Ana Paula Amariz-
Autor(es): dc.creatorAntunes, Lidiane Rodrigues-
Autor(es): dc.creatorRichard, Sylvain-
Autor(es): dc.creatorGuimarães, Homero Nogueira-
Autor(es): dc.creatorGuimarães, Andrea Grabe-
Data de aceite: dc.date.accessioned2025-08-21T15:10:07Z-
Data de disponibilização: dc.date.available2025-08-21T15:10:07Z-
Data de envio: dc.date.issued2019-04-15-
Data de envio: dc.date.issued2019-04-15-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11013-
Fonte completa do material: dc.identifierhttps://www.cambridge.org/core/journals/parasitology/article/reduced-cardiotoxicity-and-increased-oral-efficacy-of-artemether-polymeric-nanocapsules-in-plasmodium-bergheiinfected-mice/6932F5098D21304208C64C96DF709932-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1004187-
Descrição: dc.descriptionArtemether (ATM) cardiotoxicity, its short half-life and low oral bioavailability are the major limiting factors for its use to treat malaria. The purposes of this work were to study free-ATM and ATM-loaded poly-ε-caprolactone nanocapules (ATM-NC) cardiotoxicity and oral efficacy on Plasmodium berghei-infected mice. ATM-NC was obtained by interfacial polymer deposition and ATM was associated with polymeric NC oily core. For cardiotoxicity evaluation, male black C57BL6 uninfected or P. berghei-infected mice received, by oral route twice daily/4 days, vehicle (sorbitol/carboxymethylcellulose), blank-NC, free-ATM or ATMNC at doses 40, 80 or 120 mg kg−1 . Electrocardiogram (ECG) lead II signal was obtained before and after treatment. For ATM efficacy evaluation, female P. berghei-infected mice were treated the same way. ATM-NC improved antimalarial in vivo efficacy and reduced mice mortality. Free-ATM induced significantly QT and QTc intervals prolongation. ATMNC (120 mg kg−1 ) given to uninfected mice reduced QT and QTc intervals prolongation 34 and 30%, respectively, compared with free-ATM. ATM-NC given to infected mice also reduced QT and QTc intervals prolongation, 28 and 27%, respectively. For the first time, the study showed a nanocarrier reducing cardiotoxicity of ATM given by oral route and it was more effective against P. berghei than free-ATM as monotherapy.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectElectrocardiogram-
Palavras-chave: dc.subjectMalaria-
Palavras-chave: dc.subjectQT interval-
Título: dc.titleReduced cardiotoxicity and increased oral efficacy of artemether polymeric nanocapsules in Plasmodium berghei-infected mice.-
Aparece nas coleções:Repositório Institucional - UFOP

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