Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults : a population‑based study.

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Autor(es): dc.creatorSabião, Thaís da Silva-
Autor(es): dc.creatorMenezes Júnior, Luiz Antônio Alves de-
Autor(es): dc.creatorBatista, Aline Priscila-
Autor(es): dc.creatorMoura, Samara Silva de-
Autor(es): dc.creatorMeireles, Adriana Lúcia-
Autor(es): dc.creatorMenezes, Mariana Carvalho de-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorCarraro, Júlia Cristina Cardoso-
Data de aceite: dc.date.accessioned2025-08-21T15:08:30Z-
Data de disponibilização: dc.date.available2025-08-21T15:08:30Z-
Data de envio: dc.date.issued2025-03-06-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19844-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-024-57558-1-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1003313-
Descrição: dc.descriptionMental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is under a Creativ e Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: PDF do artigo.-
Título: dc.titleInteraction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults : a population‑based study.-
Aparece nas coleções:Repositório Institucional - UFOP

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