Low doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs.

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Autor(es): dc.creatorMelo, Lilian-
Autor(es): dc.creatorCaldas, Ivo Santana-
Autor(es): dc.creatorAzevedo, Maíra Araújo-
Autor(es): dc.creatorGonçalves, Karolina Ribeiro-
Autor(es): dc.creatorNascimento, Alvaro Fernando da Silva do-
Autor(es): dc.creatorFigueiredo, Vivian Paulino-
Autor(es): dc.creatorDiniz, Lívia de Figueiredo-
Autor(es): dc.creatorLima, Wanderson Geraldo de-
Autor(es): dc.creatorTorres, Rosália Morais-
Autor(es): dc.creatorBahia, Maria Terezinha-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Data de aceite: dc.date.accessioned2025-08-21T15:06:52Z-
Data de disponibilização: dc.date.available2025-08-21T15:06:52Z-
Data de envio: dc.date.issued2017-06-02-
Data de envio: dc.date.issued2017-06-02-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7858-
Fonte completa do material: dc.identifierhttp://www.ajtmh.org/content/84/2/325-
Fonte completa do material: dc.identifierhttps://doi.org/10.4269/ajtmh.2011.10-0451-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002691-
Descrição: dc.descriptionChagas cardiomyopathy remodeling is based on the presence of Trypanosoma cruzi in heart tissue and on the complex inflammatory response leading to a myocardium fibrosis and alterations in conductive and functional heart parameters. This study aims to evaluate Simvastatin on the inflammatory response and heart functionality using dogs infected with Y strain of T. cruzi . Animals were treated daily with Simvastatin (20 mg) for 6 months and submitted to clinical and immunopathological evaluations. Simvastatin reduced heart expression and serum levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) but not interleukin-10 (IL-10), possibly favoring blood parasitism but reducing inflammation and fibrosis in the left ventricle and right atrium. Simvastatin also ameliorated ejection fraction, diastolic diameter, and mass index of the left ventricle 6 months after infection. This study suggests that more investigation should be performed on the use of statins as a prophylactic therapy against cardiac remodeling because of their effects on modifying immune response and benefiting functional parameters in dogs with T. cruzi -induced ventricular dysfunctions.-
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Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleLow doses of Simvastatin therapy ameliorate cardiac inflammatory remodeling in Trypanosoma cruzi-Infected dogs.-
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