In silico pharmacological prediction and cytotoxicity of flavonoids glycosides identified by UPLC-DAD-ESI-MS/MS in extracts of Humulus lupulus leaves cultivated in Brazil.

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Autor(es): dc.creatorSilva, Regislainy Gomes da-
Autor(es): dc.creatorAlmeida, Tamires Cunha-
Autor(es): dc.creatorReis, Adriana Cotta Cardoso-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorSilva, Glenda Nicioli da-
Autor(es): dc.creatorSousa, Hildeberto Caldas de-
Autor(es): dc.creatorAlmeida, Vera Lúcia de-
Autor(es): dc.creatorLopes, Júlio César Dias-
Autor(es): dc.creatorSouza, Gustavo Henrique Bianco de-
Data de aceite: dc.date.accessioned2025-08-21T15:06:48Z-
Data de disponibilização: dc.date.available2025-08-21T15:06:48Z-
Data de envio: dc.date.issued2021-09-16-
Data de envio: dc.date.issued2021-09-16-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/13744-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1803308-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2020.1803308-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002667-
Descrição: dc.descriptionEthanolic (EB) extract and hexanic (SH) and hydromethanolic (SEM) sub-extracts of Humulus lupulus leaves were submitted to cytotoxicity evaluation and to phytochemical methods. The effect of EB and SEM on cellular cycle was evaluated by propidium iodide method and the phases were quantified through flow cytometry. The cytotoxicity assessment was done using T24 and MRC5 cells, with EB and SEM (25–1200 mg/mL). By means of UPLC-DADMS/MS data were identified the flavonoids astragaline, nicotiflorin, kaempferol-7-O-rutinoside, robinin, hyperin, rutin, quercetin-7-Orutinoside and manghaslin. EB (800 mg/mL) and SEM (1200 mg/mL) reduces the T24 cell viability. These extracts at 25 mg/mL stimulate the growth of MRC5 cells, evidencing a selective cytotoxicity. After 24 h of the treatment with extracts was not observed cycle arrest of T24 cells. The bioactivity prediction of the flavonoids was evaluated in silico through in house Active-IT software and PASSonline which indicated potential activity as antitumoral, cytotoxic, anti-inflammatory, antiparasitic, antimicrobial, antiviral and others.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleIn silico pharmacological prediction and cytotoxicity of flavonoids glycosides identified by UPLC-DAD-ESI-MS/MS in extracts of Humulus lupulus leaves cultivated in Brazil.-
Aparece nas coleções:Repositório Institucional - UFOP

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