Antiproliferative effect of benzophenones and their infl uence on cathepsin activity.

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Autor(es): dc.creatorMurata, Ramiro Mendonça-
Autor(es): dc.creatorYatsuda, Regiane-
Autor(es): dc.creatorSantos, Marcelo Henrique dos-
Autor(es): dc.creatorKohn, Luciana K.-
Autor(es): dc.creatorMartins, Felipe Terra-
Autor(es): dc.creatorNagem, Tanus Jorge-
Autor(es): dc.creatorAlencar, Severino Matias de-
Autor(es): dc.creatorCarvalho, João Ernesto de-
Autor(es): dc.creatorRosalen, Pedro Luiz-
Data de aceite: dc.date.accessioned2025-08-21T15:06:34Z-
Data de disponibilização: dc.date.available2025-08-21T15:06:34Z-
Data de envio: dc.date.issued2017-06-08-
Data de envio: dc.date.issued2017-06-08-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7922-
Fonte completa do material: dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/ptr.2954/abstract-
Fonte completa do material: dc.identifierhttps://doi.org/10.1002/ptr.2954-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002580-
Descrição: dc.descriptionThe antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated garciniaphenone and the tetraprenylated benzophenone 7-epiclusianone, was investigated against human cancer cell lines. The antiproliferative activity on melanoma (UACC-62), breast (MCF-7), drug-resistant breast (NCI-ADR), lung/non-small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786-0), lung (NCI-460) and tongue (CRL-1624 and CRL-1623) cancer cells was determined using spectrophotometric quantifi cation of the cellular protein content. The effect of these benzophenones on the activity of cathepsins B and G was also investigated. Garciniaphenone displayed cytostatic activity in all cell lines, whereas 7- epiclusianone showed a dose-dependent cytotoxic effect. The IC50 values for cell proliferation revealed that 7-epiclusianone is more active than garciniaphenone against most of the cell lines. Furthermore, the antiproliferative effects demonstrated by garciniaphenone and 7-epiclusianone were related to their cathepsin inhibiting properties. In conclusion, 7-epiclusianone is a promising naturally occurring agent which displays multiple inhibitory effects which may be working in concert to inhibit cancer cell proliferation in vitro. The putative pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAntiproliferative-
Palavras-chave: dc.subjectCathepsin-
Palavras-chave: dc.subjectRheedia brasiliensis-
Palavras-chave: dc.subjectGarciniaphenone-
Título: dc.titleAntiproliferative effect of benzophenones and their infl uence on cathepsin activity.-
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