Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorDelolo, Fábio Godoy-
Autor(es): dc.creatorAlvarez Hernández, Anislay-
Autor(es): dc.creatorMocelo, Raúl-
Autor(es): dc.creatorPlutin, Ana M.-
Autor(es): dc.creatorCominetti, Márcia Regina-
Autor(es): dc.creatorCastellano, Eduardo Ernesto-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:05:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:05:57Z-
Data de envio: dc.date.issued2016-10-05-
Data de envio: dc.date.issued2016-10-05-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7033-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.jinorgbio.2015.04.008-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002384-
Descrição: dc.descriptionFour ruthenium(II)-based complexeswith N-(acyl)-N′,N′-(disubstituted)thiourea derivatives (Th)were obtained. The compounds, with the general formula trans-[Ru(PPh3)2(Th)(bipy)]PF6, interact with bovine serum albumin (BSA) and DNA. BSA-binding constants, which were in the range of 3.3–6.5 × 104 M−1, and the thermodynamic parameters (ΔG, ΔH and ΔS), suggest spontaneous interactions with this protein by electrostatic forces due to the positive charge of the complexes. Also, binding constant by spectrophotometric DNA titration (Kb = 0.8–1.8 × 104 M−1) and viscosity studies indicate weak interactions between the complexes and DNA. Cytotoxicity assays against DU-145 (prostate cancer) and A549 (lung cancer) tumour cells revealed that the complexes are more active in tumour cells than in normal (L929) cells, and that they present high cytotoxicity (low IC50 values) compared with the reference metallodrug, cisplatin.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico Journal of Inorganic Biochemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611287599.-
Palavras-chave: dc.subjectAcylthiourea ligands-
Palavras-chave: dc.subjectProstate cancer-
Palavras-chave: dc.subjectLung cancer-
Título: dc.titleRu(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands : synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.