Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz.

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Autor(es): dc.creatorMoraes, Sabrina Zelice da Cruz de-
Autor(es): dc.creatorShan, Andrea Yu Kwan Villar-
Autor(es): dc.creatorMelo, Marlange Almeida Oliveira-
Autor(es): dc.creatorSilva, Juliane Pereira da-
Autor(es): dc.creatorPassos, Fabiolla Rocha Santos-
Autor(es): dc.creatorGraça, Ariel de Souza-
Autor(es): dc.creatorAraújo, Brancilene Santos de-
Autor(es): dc.creatorQuintans, Jullyana de Souza Siqueira-
Autor(es): dc.creatorQuintans Júnior, Lucindo José-
Autor(es): dc.creatorBarreto, Emiliano de Oliveira-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorEstevam, Charles dos Santos-
Data de aceite: dc.date.accessioned2025-08-21T15:04:50Z-
Data de disponibilização: dc.date.available2025-08-21T15:04:50Z-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14096-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S0378874119319257?via%3Dihub-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.jep.2020.112563-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002063-
Descrição: dc.descriptionEthnopharmacology relevance: Poncianella pyramidalis (Leguminosae) is a Caatinga plant used in folk medicine because of its pharmacological properties, which include anti-inflammatory action. However, chemical compounds re sponsible for this effect have not yet been identified. Aim of the study: This study aimed to evaluate the antioxidant, antinociceptive and anti-inflammatory effects of the ethyl acetate fraction from the inner bark of P. pyramidalis. Material and methods: Total phenol content (TP) was estimated using the Folin-Ciocalteu reagent, while in vitro antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Chemical identification was done using LC-PDA/MS and LC-ESI/MS/MS. In vivo antinociceptive and anti-in flammatory properties were investigated using formalin, mechanical hypernociception and carrageenan-induced pleurisy assays in mice. Results: TP was 525.08 ± 17.49 μg mg−1 gallic acid equivalent. The ethyl acetate fraction (EAF) inhibited 87.76% of the DPPH radical with an EC50 of 22.94 μg mL−1 and Antioxidant Activity Index of 1.74. LC-PDA/MS and LC-ESI/MS/MS identified 15 compounds that are mostly derived from gallic and ellagic acids. Regarding in vivo antinociceptive and anti-inflammatory activity, EAF (100 mg kg-1) significantly reduced the nociceptive response in the second phase of the formalin assay by 50% (p < 0.01) compared with the control group. In the hypernociception test, a significant (p < 0.001) anti-hyperalgesic effect of EAF (100 mg kg-1) was observed up to the third hour of evaluation (p < 0.001). In the carrageenan assay, EAF (100 mg kg-1) was shown to inhibit protein extravasation, increase total leukocytes and neutrophils, and inhibit mononuclear cells. Conclusion: These results demonstrate EAF from the inner bark of P. pyramidalis has strong in vitro antioxidant effect as well as in vivo antinociceptive and anti-inflammatory activities, which may be attributed to the bark being rich in phenolic compounds derived from gallic acid.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPhenolic-
Palavras-chave: dc.subjectCarrageenan-
Palavras-chave: dc.subjectHyperalgesic-
Palavras-chave: dc.subjectHypernociception-
Título: dc.titleAntinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz.-
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