Metabolic imprinting induced by a high-sugar diet : efects on microRNA expression and insulin resistance in young rats.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorQueiroz, Karina Barbosa de-
Autor(es): dc.creatorEvangelista, Elísio Alberto-
Autor(es): dc.creatorCota, Renata Guerra de Sá-
Data de aceite: dc.date.accessioned2025-08-21T15:04:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:04:46Z-
Data de envio: dc.date.issued2023-05-03-
Data de envio: dc.date.issued2023-05-03-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16517-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s11033-022-07473-3-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s11033-022-07473-3-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1002044-
Descrição: dc.descriptionBackground Metabolic imprinting describes associations between nutritional experiences of early life and the develop- ment of diseases later in life. The goal of this study was to evaluate the metabolic imprinting induced by a high-sugar diet (HSD) and its efects on microRNA (miRNA) expression and insulin resistance (IR) in young rats. We assessed the efects of expression of adipogenic (miR-200c) and metabolic (miR-126a) miRNAs in retroperitoneal white adipose tissue (rWAT) on IR development. Methods and results Weaned male Wistar rats (N=6) were fed a standard chow diet or HSD (68% carbohydrates) for 4-, 8-, or 12-weeks. Serum samples were collected to measure triacylglycerol and VLDL-cholesterol, and we assessed glucometa- bolic parameters (glucose, insulin, HOMA-IR, and QUICKI). rWAT was collected for microRNA analysis (N=3). The HSD resulted in body fat accretion and IR after 8-weeks, which resolved by 12-weeks. Moreover, the HSD had a time-dependent efect on miRNA relative expression, downregulating rno-miR-200c-3p at week 8 and rno-miR-126a-3p at week 12. Conclusions MiR-200 family dysregulation has been related to IR, and miR-126a downregulation could be associated with the improvement in IR observed after a 12-week HSD feeding period. This is the frst time that excessive sugar intake post- weaning has been associated with miRNA production by rWAT with an impact on IR development.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectMetabolic imprinting-
Palavras-chave: dc.subjectPost-weaning-
Palavras-chave: dc.subjectmiRNA-
Palavras-chave: dc.subjectHigh-sugar diet-
Título: dc.titleMetabolic imprinting induced by a high-sugar diet : efects on microRNA expression and insulin resistance in young rats.-
Aparece nas coleções:Repositório Institucional - UFOP

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