Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.

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Autor(es): dc.creatorGonçalves, Pamela Rosa-
Autor(es): dc.creatorSousa, Luciana Pereira de-
Autor(es): dc.creatorMaia, Aline Barbosa-
Autor(es): dc.creatorGomes, Flávia Lima Ribeiro-
Autor(es): dc.creatorGress, Caroline Cristhiani Tavares de Lima-
Autor(es): dc.creatorWerneck, Guilherme Loureiro-
Autor(es): dc.creatorSouza, Diogo Onofre-
Autor(es): dc.creatorAlmeida, Roberto Farina de-
Autor(es): dc.creatorRibeiro, Cláudio Tadeu Daniel-
Data de aceite: dc.date.accessioned2025-08-21T15:04:13Z-
Data de disponibilização: dc.date.available2025-08-21T15:04:13Z-
Data de envio: dc.date.issued2023-12-13-
Data de envio: dc.date.issued2023-12-13-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17936-
Fonte completa do material: dc.identifierhttps://doi.org/10.3389/fimmu.2022.1021211-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1001886-
Descrição: dc.descriptionData recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of nonsevere rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12th day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectBehavior-
Palavras-chave: dc.subjectCognitive dysfunction-
Palavras-chave: dc.subjectDiphtheria-tetanus vaccine-
Palavras-chave: dc.subjectImmunomodulation-
Palavras-chave: dc.subjectNon-severe experimental malaria-
Título: dc.titleDynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria.-
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