Ru(II)-naphthoquinone complexes with high selectivity for triple negative breast cancer.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorPeterson, Erica J.-
Autor(es): dc.creatorCarroccia, Murilo César-
Autor(es): dc.creatorCominetti, Márcia Regina-
Autor(es): dc.creatorDeflon, Victor Marcelo-
Autor(es): dc.creatorFarrell, Nicholas P.-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Data de aceite: dc.date.accessioned2025-08-21T15:03:46Z-
Data de disponibilização: dc.date.available2025-08-21T15:03:46Z-
Data de envio: dc.date.issued2022-01-09-
Data de envio: dc.date.issued2022-01-09-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14300-
Fonte completa do material: dc.identifierhttps://pubs.rsc.org/en/content/articlelanding/2020/dt/d0dt01091j-
Fonte completa do material: dc.identifierhttps://doi.org/10.1039/D0DT01091J-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1001752-
Descrição: dc.descriptionSix new ruthenium(II) complexes with lapachol (Lap) and lawsone (Law) with the general formula [Ru(L)(P– P)(bipy)]PF6, where L = Lap or Law, P–P = 1,2’-bis(diphenylphosphino)ethane (dppe), 1,4’-bis(diphenyl phosphino)butane (dppb), 1,1’-bis(diphenylphosphino)ferrocene (dppf) and bipy = 2,2’-bipyridine, were synthesized, fully characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV vis, IR spectroscopies and three of them by X-ray crystallography. All six complexes were active against breast (MCF-7 and MDA-MB-231) and prostate (DU-145) cancer cell lines with lower IC50 values than cis platin. Complex [Ru(Lap)(dppe)(bipy)]PF6 (1a) showed significant selectivity for MDA-MB-231, a model of triple-negative breast cancer (TNBC), as compared to the “normal-like” human breast epithelial cell line, MCF-10A. Complex (1a) inhibited TNBC colony formation and induced loss of cellular adhesion. Furthermore, the complex (1a) induced mitochondrial dysfunction and generation of ROS, as is involved in the apoptotic cell death pathway. Preferential cellular uptake of complex (1a) was observed in MDA-MB-231 cells compared to MCF-10A cells, consistent with the observed selectivity for tumorigenic vs. non-tumorigenic cells. Taken together, these results indicate that ruthenium complexes containing lapachol and lawsone as ligands are promising candidates as chemotherapeutic agents.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleRu(II)-naphthoquinone complexes with high selectivity for triple negative breast cancer.-
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