Tratamento da baixa estatura idiopática : experiência da unidade de endocrinologia pediátrica

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPereira, Rosana Marques-
Autor(es): dc.contributorUniversidade Federal do Paraná. Setor de Ciências da Saúde. Curso de Especialização em Endocrinologia Pediátrica-
Autor(es): dc.creatorBatista, Letícia Rocha-
Data de aceite: dc.date.accessioned2025-09-01T12:39:23Z-
Data de disponibilização: dc.date.available2025-09-01T12:39:23Z-
Data de envio: dc.date.issued2025-06-27-
Data de envio: dc.date.issued2025-06-27-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/1884/54617-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/1884/54617-
Descrição: dc.descriptionOrientadora: Profª. Drª. Rosana Marques Pereira-
Descrição: dc.descriptionMonografia (especialização) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Curso de Especialização em Endocrinologia Pediátrica-
Descrição: dc.descriptionInclui referências-
Descrição: dc.descriptionResumo : Objective: To evaluate the efficacy of treatment of children and adolescents with idiopathic short stature (ISS) attended at a Public University Hospital in Brazil. Patients and methods: Review of 134 charts of patients with indication for recombinant growth hormone (GHr) between May 2007 and May 2017 and collection of the following data: sex, chronological age, weight and length at birth, pubertal stage, Z-score of target stature (TS), GH peak with clonidine and/or insulin hypoglycemia, prescribed GHr dose, adjuvant treatment, duration of treatment, final stature (FS) Z-score. Stature Z-score and Z-score of the final stature prevision (FSP) were obtained pre-treatment and annually. Results: 65 patients fulfilled the ISS criteria; 33 were on treatment (> 12 months) and 10 reached FS. IGF-1 was normal in 92.3% and all had one or both of the responsive stimulus tests (peak > 5.0 ng/mL). The Z-score of stature at the 1st, 2nd, 3rd, 4th (p <0.01) and 5th (p = 0.01) years of treatment were higher than the Z-score of initial stature. The FSP Z-score at the 1st, 2nd, 3rd (p <0.01) and 4th years (p = 0.01) of treatment was higher than the Z-score of the initial FSP. All patients who achieved FS used adjuvant treatment. The FS Z-score was not different from the TS Z-score (p = 0.24). Stature gain ranged from 0.9 to 7.9 cm. Conclusion: The treatment of children with ISS is safe and effective, but with great variability of response. Its administration should be individualized considering psychosocial benefits, adverse effects and costs.-
Formato: dc.format1 recurso online : PDF.-
Formato: dc.formatapplication/pdf-
Formato: dc.formatapplication/pdf-
Palavras-chave: dc.subjectEstatura-
Palavras-chave: dc.subjectHôrmonio do crescimento humano-
Título: dc.titleTratamento da baixa estatura idiopática : experiência da unidade de endocrinologia pediátrica-
Aparece nas coleções:Repositório Institucional - Rede Paraná Acervo

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