Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: An observational cohort study

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNegrato, Carlos A.-
Autor(es): dc.creatorRafacho, Alex-
Autor(es): dc.creatorNegrato, Giovana-
Autor(es): dc.creatorTeixeira, Marcio F.-
Autor(es): dc.creatorAraujo, Cesar A. R.-
Autor(es): dc.creatorVieira, Leila-
Autor(es): dc.creatorSilva, Cesar A.-
Autor(es): dc.creatorDate, Sueli K.-
Autor(es): dc.creatorDemarchi, Ana C.-
Autor(es): dc.creatorGomes, Marilia B.-
Data de aceite:
Data de disponibilização:
Data de envio:
Data de envio:
Data de envio:
Fonte completa do material: dc.identifier
Fonte completa do material: dc.identifier
Fonte: dc.identifier.uri
Descrição: dc.descriptionAims: The effects of glargine insulin therapy in pregnancies are not well established. We compared maternal and neonatal outcomes of women with pregestational and gestational diabetes treated with glargine or NPH insulin.Methods: A prospective cohort study was conducted analyzing outcomes from 56 women with pregestational and 82 with gestational diabetes treated with either insulin regimen.Results: Comparisons were performed among 138 women: 56 with pregestational and 82 with gestational diabetes. In relation to maternal complications, worsening of retinopathy and nephropathy, preeclampsia, micro and macroalbuminuria, and all kinds of hypoglycemia were found higher in women with pregestational diabetes NPH-treated vs. glargine-treated. In women with gestational diabetes NPH-treated, it was observed increased incidence of prepregnancy and new-onset pregnancy hypertension, micro and macroalbuminuria, as well as mild and frequent hypoglycemia, compared to glargine-treated. Among the neonatal outcomes, 1-min Apgar score <7, necessity of intensive care unit and fetal death in pregestational, while jaundice and congenital malformations in gestational diabetes, respectively, were more frequently observed in infants born to NPH-treated, compared to glargine-treated.Conclusions: Glargine use during pregnancy from preconception through delivery, showed to be safe since it is associated with decreased maternal and neonatal adverse outcomes compared with NPH insulin-treated patients. (C) 2010 Elsevier B.V. All rights reserved.-
Formato: dc.format46-51-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationDiabetes Research and Clinical Practice-
Relação: dc.relation2.548-
Relação: dc.relation1,538-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectGestational diabetes-
Palavras-chave: dc.subjectInsulin therapy-
Palavras-chave: dc.subjectMaternal complications-
Palavras-chave: dc.subjectNeonatal outcomes-
Título: dc.titleGlargine vs. NPH insulin therapy in pregnancies complicated by diabetes: An observational cohort study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.