Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDa Silva, Aleksandro S.-
Autor(es): dc.creatorMunhoz, Thiago D.-
Autor(es): dc.creatorFaria, Joice L.M.-
Autor(es): dc.creatorVargas-Hérnandez, Giovanni-
Autor(es): dc.creatorMachado, Rosangela Z.-
Autor(es): dc.creatorLuz, Nathalia C.-
Autor(es): dc.creatorMoritz, Cesar E.J.-
Autor(es): dc.creatorCasali, Emerson A.-
Autor(es): dc.creatorBottari, Nathieli B.-
Autor(es): dc.creatorStefani, Lenita M.-
Autor(es): dc.creatorTinucci-Costa, Mirela-
Data de aceite: dc.date.accessioned2021-03-10T20:02:20Z-
Data de disponibilização: dc.date.available2021-03-10T20:02:20Z-
Data de envio: dc.date.issued2014-05-27-
Data de envio: dc.date.issued2014-05-27-
Data de envio: dc.date.issued2013-10-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vetmic.2013.06.033-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/76882-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/76882-
Descrição: dc.descriptionThe aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P< 0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P< 0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. © 2013 Elsevier B.V.-
Formato: dc.format602-606-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Microbiology-
Relação: dc.relation2.524-
Relação: dc.relation1,175-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectAdenosine-
Palavras-chave: dc.subjectAdenosine deaminase-
Palavras-chave: dc.subjectCanine-
Palavras-chave: dc.subjectEhrlichia canis-
Palavras-chave: dc.subjectadenosine-
Palavras-chave: dc.subjectadenosine deaminase-
Palavras-chave: dc.subjectadenosine diphosphate-
Palavras-chave: dc.subjectadenosine phosphate-
Palavras-chave: dc.subjectadenosine triphosphate-
Palavras-chave: dc.subjecthypoxanthine-
Palavras-chave: dc.subjectpurine-
Palavras-chave: dc.subjecturic acid-
Palavras-chave: dc.subjectxanthine-
Palavras-chave: dc.subjectanimal experiment-
Palavras-chave: dc.subjectanimal model-
Palavras-chave: dc.subjectanimal tissue-
Palavras-chave: dc.subjectblood level-
Palavras-chave: dc.subjectcanine ehrlichiosis-
Palavras-chave: dc.subjectcontrolled study-
Palavras-chave: dc.subjectdisease association-
Palavras-chave: dc.subjectdog-
Palavras-chave: dc.subjectenzyme activity-
Palavras-chave: dc.subjectexperimental infection-
Palavras-chave: dc.subjectnonhuman-
Palavras-chave: dc.subjectpathogenesis-
Palavras-chave: dc.subjectprotein expression-
Palavras-chave: dc.subjectAnimalia-
Palavras-chave: dc.subjectCanis familiaris-
Título: dc.titleInfluence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis-
Tipo de arquivo: dc.typelivro digital-
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