Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorChuffa, Luiz Gustavo A.-
Autor(es): dc.creatorSeiva, Fábio R.F.-
Autor(es): dc.creatorFávaro, Wagner José-
Autor(es): dc.creatorAmorim, João Paulo A.-
Autor(es): dc.creatorTeixeira, Giovana R.-
Autor(es): dc.creatorMendes, Leonardo O.-
Autor(es): dc.creatorFioruci-Fontanelli, Beatriz A.-
Autor(es): dc.creatorPinheiro, Patricia Fernanda F.-
Autor(es): dc.creatorMartinez, Marcelo-
Autor(es): dc.creatorMartinez, Francisco Eduardo-
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Descrição: dc.descriptionChronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100. μg/100. g. BW/day) on sex hormones and steroid receptors in the ovaries, oviducts and uteri of ethanol-preferring rats. After 150 days of treatment, animals were euthanized, and tissue samples were harvested to evaluate androgen, estrogen, progesterone and melatonin receptor subunits (AR, ER-α and ER-β, PRA, PRB and MT1R, respectively). Melatonin decreased estradiol (E2) and increased progesterone (P4) and 6-sulfatoxymelatonin (6-STM), while an ethanol-melatonin combination reduced both P4 and E2. Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination. Oviduct ER-α, ER-β and uterine ER-β were down-regulated by either ethanol or melatonin. Conversely, ovarian PRA and PRB were positively regulated by ethanol and ethanol-melatonin combination, whereas PRA was down-regulated in the uterus and oviduct after ethanol consumption. MT1R was increased in ovaries and uteri of melatonin-treated rats. Ethanol and melatonin exert opposite effects on E2 and P4, and they differentially regulate the expression of sex steroid receptors in female reproductive tissues. © 2013 Elsevier Inc.-
Formato: dc.format40-49-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
Relação: dc.relation2.580-
Relação: dc.relation0,846-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectEthanol-
Palavras-chave: dc.subjectFemale reproductive tissue-
Palavras-chave: dc.subjectMelatonin-
Palavras-chave: dc.subjectSex hormone-
Palavras-chave: dc.subjectSex steroid receptor-
Palavras-chave: dc.subject6 hydroxymelatonin o sulfate-
Palavras-chave: dc.subjectalcohol-
Palavras-chave: dc.subjectandrogen receptor-
Palavras-chave: dc.subjectbeta actin-
Palavras-chave: dc.subjectdaidzein-
Palavras-chave: dc.subjectestradiol-
Palavras-chave: dc.subjectestrogen receptor alpha-
Palavras-chave: dc.subjectestrogen receptor beta-
Palavras-chave: dc.subjectgenistein-
Palavras-chave: dc.subjectmelatonin-
Palavras-chave: dc.subjectmelatonin 1 receptor-
Palavras-chave: dc.subjectprogesterone-
Palavras-chave: dc.subjectprogesterone receptor A-
Palavras-chave: dc.subjectprogesterone receptor B-
Palavras-chave: dc.subjectalcohol consumption-
Palavras-chave: dc.subjectalcoholism-
Palavras-chave: dc.subjectanimal experiment-
Palavras-chave: dc.subjectanimal tissue-
Palavras-chave: dc.subjectcontrolled study-
Palavras-chave: dc.subjectdietary intake-
Palavras-chave: dc.subjectenzyme activity-
Palavras-chave: dc.subjectenzyme regulation-
Palavras-chave: dc.subjectfemale-
Palavras-chave: dc.subjectnonhuman-
Palavras-chave: dc.subjectnutritional assessment-
Palavras-chave: dc.subjectovary-
Palavras-chave: dc.subjectoviduct-
Palavras-chave: dc.subjectprotein expression-
Palavras-chave: dc.subjectprotein function-
Palavras-chave: dc.subjectrat-
Palavras-chave: dc.subjectuterus-
Título: dc.titleMelatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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