Distinct regions of loss of heterozygosity on 22q at different sites of head and neck squamous cell carcinomas

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDos Reis, Patricia Pintor-
Autor(es): dc.creatorPoli-Frederico, Regina Célia-
Autor(es): dc.creatorDos Santos, Rodrigo Mattos-
Autor(es): dc.creatorNishimoto, Ines Nobuko-
Autor(es): dc.creatorKowalski, Luiz Paulo-
Autor(es): dc.creatorRogatto, Silvia Regina-
Data de aceite: dc.date.accessioned2021-03-10T19:19:38Z-
Data de disponibilização: dc.date.available2021-03-10T19:19:38Z-
Data de envio: dc.date.issued2014-05-27-
Data de envio: dc.date.issued2014-05-27-
Data de envio: dc.date.issued2002-04-10-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/66871-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/66871-
Descrição: dc.descriptionBackground: Frequent loss of heterozygosity (LOH) has been reported in many types of cancer, including head and neck carcinomas. Somatic deletions involving specific chromosomal regions are strongly associated with inactivation of the allele of a tumor suppressor gene located within the deleted region. In most studies concerning LOH in head and neck squamous cell carcinomas (HNSCC) the different anatomical sites are not distinguished. The behavior of tumors arising at various sites differs significantly, however, suggesting different intrinsic tumor properties. In this study we compared the LOH on 22q and its relationship to clinicopathological parameters at the three major sites of HNSCC: oral cavity, larynx and pharynx. Material/Methods: LOH and microsatellite instability (MSI) were studied using seven polymorphic microsatellite markers mapped to the 22q11-q13.3 region in 37 oral, 32 laryngeal, and 31 pharyngeal carcinomas. Results: Two separate regions of LOH were identified in the laryngeal (22q11.2-12.1) and oral cavity (22q13.1-13.31) tumors. When the different anatomical sites were compared, a statistically significant difference was found between the presence of LOH at D22S421 (p<0.001), D22S315 (p=0.014) and D22S929 (p=0.026) in the laryngeal tumors. Conclusions: These data suggest that distinct regions on 22q are involved in LOH in oral cavity and laryngeal tumorigenesis but do not support a similar association between the development of pharyngeal tumors and genes located on 22q. These findings implicate the presence of different tumor suppressor genes mapping to distinct regions on chromosome 22q in oral and laryngeal carcinomas.-
Idioma: dc.languageen-
Relação: dc.relationMedical Science Monitor-
Relação: dc.relation0,619-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectChromosome 22-
Palavras-chave: dc.subjectLaryngeal tumors-
Palavras-chave: dc.subjectLoss of heterozygosity-
Palavras-chave: dc.subjectMicrosatellite instability-
Palavras-chave: dc.subjectOral cavity tumors-
Palavras-chave: dc.subjectPharyngeal tumors-
Palavras-chave: dc.subjectallele-
Palavras-chave: dc.subjectcarcinogenesis-
Palavras-chave: dc.subjectchromosome 22q-
Palavras-chave: dc.subjectclinical feature-
Palavras-chave: dc.subjectdisease association-
Palavras-chave: dc.subjectgene deletion-
Palavras-chave: dc.subjectgene inactivation-
Palavras-chave: dc.subjectgene locus-
Palavras-chave: dc.subjecthead and neck carcinoma-
Palavras-chave: dc.subjectheterozygosity loss-
Palavras-chave: dc.subjecthistopathology-
Palavras-chave: dc.subjecthuman-
Palavras-chave: dc.subjecthuman tissue-
Palavras-chave: dc.subjectlarynx carcinoma-
Palavras-chave: dc.subjectmajor clinical study-
Palavras-chave: dc.subjectmicrosatellite instability-
Palavras-chave: dc.subjectmouth carcinoma-
Palavras-chave: dc.subjectsquamous cell carcinoma-
Palavras-chave: dc.subjectstatistical significance-
Palavras-chave: dc.subjecttumor suppressor gene-
Palavras-chave: dc.subjectAlleles-
Palavras-chave: dc.subjectCarcinoma-
Palavras-chave: dc.subjectChromosomes, Human, Pair 22-
Palavras-chave: dc.subjectGene Deletion-
Palavras-chave: dc.subjectHead and Neck Neoplasms-
Palavras-chave: dc.subjectHumans-
Palavras-chave: dc.subjectLaryngeal Neoplasms-
Palavras-chave: dc.subjectLoss of Heterozygosity-
Palavras-chave: dc.subjectMicrosatellite Repeats-
Palavras-chave: dc.subjectModels, Genetic-
Palavras-chave: dc.subjectPharyngeal Neoplasms-
Título: dc.titleDistinct regions of loss of heterozygosity on 22q at different sites of head and neck squamous cell carcinomas-
Tipo de arquivo: dc.typelivro digital-
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