Comparison of selective genotyping strategies for prediction of breeding values in a population undergoing selection

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBoligon, A. A.-
Autor(es): dc.creatorLong, N.-
Autor(es): dc.creatorAlbuquerque, Lucia Galvão de-
Autor(es): dc.creatorWeigel, K. A.-
Autor(es): dc.creatorGianola, D.-
Autor(es): dc.creatorRosa, G. J. M.-
Data de aceite: dc.date.accessioned2021-03-10T16:39:26Z-
Data de disponibilização: dc.date.available2021-03-10T16:39:26Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2012-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2527/jas2012-4857-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/4505-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/4505-
Descrição: dc.descriptionGenomewide marker information can improve the reliability of breeding value predictions for young selection candidates in genomic selection. However, the cost of genotyping limits its use to elite animals, and how such selective genotyping affects predictive ability of genomic selection models is an open question. We performed a simulation study to evaluate the quality of breeding value predictions for selection candidates based on different selective genotyping strategies in a population undergoing selection. The genome consisted of 10 chromosomes of 100 cM each. After 5,000 generations of random mating with a population size of 100 (50 males and 50 females), generation G(0) (reference population) was produced via a full factorial mating between the 50 males and 50 females from generation 5,000. Different levels of selection intensities (animals with the largest yield deviation value) in G(0) or random sampling (no selection) were used to produce offspring of G(0) generation (G(1)). Five genotyping strategies were used to choose 500 animals in G(0) to be genotyped: 1) Random: randomly selected animals, 2) Top: animals with largest yield deviation values, 3) Bottom: animals with lowest yield deviations values, 4) Extreme: animals with the 250 largest and the 250 lowest yield deviations values, and 5) Less Related: less genetically related animals. The number of individuals in G(0) and G(1) was fixed at 2,500 each, and different levels of heritability were considered (0.10, 0.25, and 0.50). Additionally, all 5 selective genotyping strategies (Random, Top, Bottom, Extreme, and Less Related) were applied to an indicator trait in generation G(0), and the results were evaluated for the target trait in generation G(1), with the genetic correlation between the 2 traits set to 0.50. The 5 genotyping strategies applied to individuals in G(0) (reference population) were compared in terms of their ability to predict the genetic values of the animals in G(1) (selection candidates). Lower correlations between genomic-based estimates of breeding values (GEBV) and true breeding values (TBV) were obtained when using the Bottom strategy. For Random, Extreme, and Less Related strategies, the correlation between GEBV and TBV became slightly larger as selection intensity decreased and was largest when no selection occurred. These 3 strategies were better than the Top approach. In addition, the Extreme, Random, and Less Related strategies had smaller predictive mean squared errors (PMSE) followed by the Top and Bottom methods. Overall, the Extreme genotyping strategy led to the best predictive ability of breeding values, indicating that animals with extreme yield deviations values in a reference population are the most informative when training genomic selection models.-
Formato: dc.format4716-4722-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Soc Animal Science-
Relação: dc.relationJournal of Animal Science-
Relação: dc.relation1.711-
Relação: dc.relation0,848-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectBayesian least absolute shrinkage and selection operator-
Palavras-chave: dc.subjectgenomic selection-
Palavras-chave: dc.subjectMolecular markers-
Palavras-chave: dc.subjectpredictive ability-
Palavras-chave: dc.subjectselective genotyping-
Título: dc.titleComparison of selective genotyping strategies for prediction of breeding values in a population undergoing selection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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