Effects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPaneque Peres, Ana Claudia-
Autor(es): dc.creatorNonaka, Paula Naomi-
Autor(es): dc.creatorCamillo de Carvalho, Paulo de Tarso-
Autor(es): dc.creatorToyama, Marcos Hikari-
Autor(es): dc.creatorMelo e Silva, Cesar Augusto-
Autor(es): dc.creatorVieira, Rodolfo de Paula-
Autor(es): dc.creatorDolhnikoff, Marisa-
Autor(es): dc.creatorZamuner, Stella Regina-
Autor(es): dc.creatorFranco de Oliveira, Luis Vicente-
Data de aceite: dc.date.accessioned2021-03-10T16:30:16Z-
Data de disponibilização: dc.date.available2021-03-10T16:30:16Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2009-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2009.02.002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/318-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/318-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFVE - UNIVAP-
Descrição: dc.descriptionProcesso FAPESP: 07/01026-1-
Descrição: dc.descriptionThe present study evaluated the effects of an intramuscular injection of Tityus serrulatus venom (TsV) (0.67 mu g/g) on lung mechanics and lung inflammation at 15, 30, 60 and 180 min after inoculation. TsV inoculation resulted in increased lung elastance when compared with the control group (p < 0.001): these values were significantly higher at 60 min than at 15 and 180 min (p < 0.05). Resistive pressure (Delta P(1)) values decreased significantly at 30, 60 and 180 min after TsV injection (p < 0.001). TsV inoculation resulted in increased lung inflammation, characterised by an increased density of mononuclear cells at 15, 30, 60 and 180 min after TsV injection when compared with the control group (p < 0.001). TsV inoculation also resulted in an increased pulmonary density of polymorphonuclear cells at 15, 30 and 60 min following injection when compared to the control group (p < 0.001). In conclusion, T serrulatus venom leads to acute lung injury, characterised by altered lung mechanics and increased pulmonary inflammation. (C) 2009 Elsevier Ltd. All rights reserved.-
Formato: dc.format779-785-
Idioma: dc.languageen-
Publicador: dc.publisherPergamon-Elsevier B.V. Ltd-
Relação: dc.relationToxicon-
Relação: dc.relation2.352-
Relação: dc.relation0,692-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectTityus serrulatus-
Palavras-chave: dc.subjectLung inflammation-
Palavras-chave: dc.subjectLung mechanics-
Palavras-chave: dc.subjectRespiratory system-
Título: dc.titleEffects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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