β-Glucan Alone or Combined with Lactobacillus acidophilus Positively Influences the Bacterial Diversity and Metabolites in the Colonic Microbiota of Type II Diabetic Patients

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Autor(es): dc.contributorFederal University of Paraíba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Antioquia-
Autor(es): dc.contributorUniversité Paris Cité-
Autor(es): dc.creatorClementino, Jéssika Rodrigues-
Autor(es): dc.creatorde Oliveira, Louise Iara Gomes-
Autor(es): dc.creatorSalgaço, Mateus Kawata-
Autor(es): dc.creatorde Oliveira, Fellipe Lopes-
Autor(es): dc.creatorMesa, Victoria-
Autor(es): dc.creatorTavares, Josean Fechine-
Autor(es): dc.creatorSilva-Pereira, Ludmilla-
Autor(es): dc.creatorRaimundo, Breno Vilas Boas-
Autor(es): dc.creatorOliveira, Karen Cristina-
Autor(es): dc.creatorMedeiros, Alexandra Ivo-
Autor(es): dc.creatorSilva, Francyeli Araújo-
Autor(es): dc.creatorSivieri, Katia-
Autor(es): dc.creatorMagnani, Marciane-
Data de aceite: dc.date.accessioned2025-08-21T18:32:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:32:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12602-025-10491-9-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309999-
Descrição: dc.descriptionβ-Glucan is a fermentable polysaccharide with prebiotic properties that has been shown to improve metabolic indicators. This study evaluated the effects of spent brewer’s yeast β-glucan (BGL) and Lactobacillus acidophilus LA-5 (106 CFU/g) (LA5) alone and in combination (LA5-BGL) on the composition of the fecal microbiome of adults with type 2 diabetes mellitus (T2DM) using the Human Gut Microbial Ecosystem Simulator (SHIME®). Short-chain fatty acids (SCFAs), ammonium ions, and cytokines (IL-6 and IL-10) were measured. BGL, LA5, and LA5-BGL increased (p < 0.05) the richness and diversity of microbial communities in the gut microbiome of individuals with T2DM. All treatments increased (p < 0.05) the abundance of Bacteroides, Alistipes, Lactobacillus, Subdoligranulum, and Acidaminococcus, along with increased (p < 0.05) production of SCFAs and anti-inflammatory cytokine (IL-10) compared to the control group. BGL treatments showed a greater increase in microbial diversity, SCFAs levels (butyric, propionic, and acetic acid), and the anti-inflammatory cytokine (IL-10). LA5 showed the highest decrease in ammonium ion levels. Results indicate that BGL may have a prebiotic and immunomodulatory effect on the fecal microbial community and metabolic indicators in adults with type 2 diabetes mellitus (T2DM). Findings underscore the role of BGL as a prebiotic food.-
Descrição: dc.descriptionLaboratory of Microbial Processes in Foods Federal University of Paraíba-
Descrição: dc.descriptionDepartment of Food and Nutrition São Paulo State University-
Descrição: dc.descriptionSchool of Nutrition and Dietetics Universidad de Antioquia-
Descrição: dc.descriptionFaculty of Pharmacy Université Paris Cité-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Health Science Center Federal University of Paraíba-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Food and Nutrition São Paulo State University-
Descrição: dc.descriptionDepartment of Biological Sciences São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationProbiotics and Antimicrobial Proteins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFunctional foods-
Palavras-chave: dc.subjectGut microbiota-
Palavras-chave: dc.subjectSHIME®-
Palavras-chave: dc.subjectShort-chain fatty acids-
Palavras-chave: dc.subjectβ-glucan-
Título: dc.titleβ-Glucan Alone or Combined with Lactobacillus acidophilus Positively Influences the Bacterial Diversity and Metabolites in the Colonic Microbiota of Type II Diabetic Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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