Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTasso, Camilla Olga-
Autor(es): dc.creatorFerrisse, Túlio Morandin-
Autor(es): dc.creatorde Oliveira, Analú Barros-
Autor(es): dc.creatorRibas, Beatriz Ribeiro-
Autor(es): dc.creatorJorge, Janaina Habib-
Data de aceite: dc.date.accessioned2025-08-21T20:30:40Z-
Data de disponibilização: dc.date.available2025-08-21T20:30:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.canep.2023.102451-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309971-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309971-
Descrição: dc.descriptionOral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of case-control studies was performed based on the Newcastle-Ottawa scale. Meta-analysis was performed to evaluate the frequency of Candida spp and the levels of microbial acetaldehyde production (MAP) being odds ratio (OR) the effect-measure applied. Eight and six studies were included in the qualitative analysis and meta-analysis, respectively. It was noted that there was a significantly higher frequency of Candida species (p = 0.0003/OR = 9.50) in patients diagnosed with OSCC than healthy patients, especially Candida krusei (p = 0.0167/OR=4.62). Candida spp., from oral cancer patients demonstrated significantly greater biofilm, biofilm metabolic activity, phospholipase, proteinase activity and a higher production of MAP (p = 0.0111/OR = 2.67). Candida species may have a potential role in OSCC development. Further studies should be conducted to elucidate the mechanism of action of Candida spp and others risk factors in the development of OSCC.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (Unesp) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University (Unesp) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: #2013/07276-1-
Descrição: dc.descriptionFAPESP: #2020/07110-0-
Descrição: dc.descriptionFAPESP: #2021/01191-0-
Descrição: dc.descriptionFAPESP: #2022/12828-2-
Idioma: dc.languageen-
Relação: dc.relationCancer Epidemiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCandida krusei-
Palavras-chave: dc.subjectCandida species-
Palavras-chave: dc.subjectMicrobial acetaldehyde production-
Palavras-chave: dc.subjectSquamous cell carcinoma-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titleCandida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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