Basal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients

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Autor(es): dc.contributorHuntington Medicina Reprodutiva - Eugin Group-
Autor(es): dc.contributorReproductive Medicine Centre-
Autor(es): dc.contributorClinica EUGIN-
Autor(es): dc.contributorFondazione IRCCS San Gerardo Dei Tintori-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorJacobs, Catherine K.-
Autor(es): dc.creatorNicolielo, Mariana-
Autor(es): dc.creatorAlegretti, José Roberto-
Autor(es): dc.creatorCanto, Mariabeatrice Dal-
Autor(es): dc.creatorRenzini, Mario Mignini-
Autor(es): dc.creatorDe Ponti, Elena-
Autor(es): dc.creatorChehin, Mauricio Barbour-
Autor(es): dc.creatorMotta, Eduardo L. A.-
Autor(es): dc.creatorLorenzon, Aline R.-
Autor(es): dc.creatorBuratini, Jose-
Data de aceite: dc.date.accessioned2025-08-21T22:10:25Z-
Data de disponibilização: dc.date.available2025-08-21T22:10:25Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10815-024-03190-x-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309927-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309927-
Descrição: dc.descriptionPurpose: To assess the impact of maternal age on the association between maternal basal FSH and aneuploidy. Methods: A retrospective study including data from 1749 blastocysts diagnosed as euploid or aneuploid by PGT-A (preimplantation genetic testing for aneuploidy). Aneuploidy incidence was compared between embryos from mothers with high vs. low basal FSH levels (above and below the group median, respectively) in total, pre-AMA (advanced maternal age; < 35 years, 198 embryos) and AMA (≥ 35 years, 1551 embryos) patient groups, separately. To control for the interference of potentially confounding variables, the association between aneuploidy and high basal FSH levels was assessed by multivariate logistic analysis in overall, pre-AMA and AMA patient groups. Results: Overall, aneuploidy rate was 9% higher (p = 0.02) in embryos from patients with high basal FSH (63.7%) compared to those with low basal FSH (58.4%). In the pre-AMA subgroup, aneuploidy incidence was 35% higher (p = 0.04) in embryos from patients with high basal FSH (53.5%) compared to those with low basal FSH (39.4%). Differently, aneuploidy occurrence did not vary between embryos from AMA patients with low (61.0%) and high (64.8%) basal FSH (p = 0.12). The multivariate analysis revealed that, in pre-AMA embryos, the association between aneuploidy occurrence and high basal FSH is independent of potential confounding variables (p = 0.04). Conclusion: Maternal basal FSH values are associated with embryo aneuploidy in pre-AMA but not in AMA patients. The present findings suggest that basal FSH is a useful parameter to assess aneuploidy risk in pre-AMA patients and reinforce the hypothesis that excessive FSH signalling can predispose to oocyte meiotic errors.-
Descrição: dc.descriptionHuntington Medicina Reprodutiva - Eugin Group-
Descrição: dc.descriptionBiogenesi Reproductive Medicine Centre-
Descrição: dc.descriptionClinica EUGIN-
Descrição: dc.descriptionMedical Physics Fondazione IRCCS San Gerardo Dei Tintori-
Descrição: dc.descriptionDepartment of Gynecology School of Medicine Federal University of Sao Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Formato: dc.format2397-2404-
Idioma: dc.languageen-
Relação: dc.relationJournal of Assisted Reproduction and Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdvanced maternal age-
Palavras-chave: dc.subjectAneuploidy-
Palavras-chave: dc.subjectBasal FSH-
Palavras-chave: dc.subjectPGT-A-
Título: dc.titleBasal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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