Antimicrobial Effect of Low-Fluoride Toothpastes Containing Polyphosphate and Polyols: An In Vitro Assessment of Inhibition Zones

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.creatorZen, Igor-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorHosida, Thayse Yumi-
Autor(es): dc.creatorSampaio, Caio-
Autor(es): dc.creatorde Morais, Leonardo Antônio-
Autor(es): dc.creatorMartins, Tamires Passadori-
Autor(es): dc.creatorMonteiro, Douglas Roberto-
Autor(es): dc.creatorPessan, Juliano Pelim-
Data de aceite: dc.date.accessioned2025-08-21T17:08:51Z-
Data de disponibilização: dc.date.available2025-08-21T17:08:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics12081333-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309914-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309914-
Descrição: dc.descriptionThis study evaluated the antimicrobial effect of toothpastes containing 200 ppm fluoride (200F), xylitol (X, 16%), erythritol (E, 4%), and sodium trimetaphosphate (TMP, 0.25%), alone or in different associations, against Streptococcus mutans (SM), Lactobacillus casei (LC), Actinomyces israelii (AI), and Candida albicans (CA). Suspensions of the micro-organisms were added to a BHI Agar medium. Five wells were made on each plate to receive toothpaste suspensions at different dilutions. Toothpastes containing no actives (placebo) or 1100 ppm F (1100F) were used as negative and positive controls. Two-way ANOVA and Tukey’s HDS test were used (p < 0.05). For SM, the largest halo was for 200F+TMP at all dilutions, followed by the 200F+X+E toothpaste (p < 0.001). For LC, the overall trend showed that the polyols effectively inhibited microbial growth, and the association with the other compounds enhanced such effects (p < 0.001). For AI, a less-defined trend was observed. For CA, the experimental toothpaste (200F+X+E+TMP) was consistently more effective than the other treatments, followed by 200F+X+E (p < 0.001). The association of polyols and TMP in a low-fluoride toothpaste effectively reduced the growth of cariogenic micro-organisms (SM, CA, and LC), suggesting that this formulation could be an interesting alternative for children due to its low fluoride content.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP-
Descrição: dc.descriptionPostgraduate Program in Health Sciences University of Western São Paulo (UNOESTE), SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectpolyphosphates-
Palavras-chave: dc.subjectsugar alcohols-
Palavras-chave: dc.subjecttoothpaste-
Título: dc.titleAntimicrobial Effect of Low-Fluoride Toothpastes Containing Polyphosphate and Polyols: An In Vitro Assessment of Inhibition Zones-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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