Combining Polymer and Cyclodextrin Strategy for Drug Release of Sulfadiazine from Electrospun Fibers

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Itajubá (UNIFEI)-
Autor(es): dc.contributorUniversidade de Araraquara (UNIARA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Juiz de Fora (UFJF)-
Autor(es): dc.creatorMorais, Diego C.-
Autor(es): dc.creatorFontes, Marina L.-
Autor(es): dc.creatorOliveira, Analú B.-
Autor(es): dc.creatorGabbai-Armelin, Paulo R.-
Autor(es): dc.creatorFerrisse, Túlio M.-
Autor(es): dc.creatorDe Oliveira, Luiz F. C.-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção-
Autor(es): dc.creatorBarud, Hernane S.-
Autor(es): dc.creatorDe Sousa, Frederico B.-
Data de aceite: dc.date.accessioned2025-08-21T22:53:32Z-
Data de disponibilização: dc.date.available2025-08-21T22:53:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics15071890-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309896-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309896-
Descrição: dc.descriptionThis study reports the fabrication of polymeric matrices through electrospinning using polymethyl methacrylate (PMMA) and poly(lactic-co-glycolic acid) (PLGA), biocompatible polymers commonly used in medical systems. These polymers were combined with an antibacterial drug, sulfadiazine sodium salt (SDS) or its supramolecular system formed with hydroxypropyl-β-cyclodextrin (HPβ/CD) at 1:1 molar ratio, aiming to assemble a transdermal drug delivery system. The formation of fibers was confirmed by scanning electron microscopy (SEM), and the fibers’ surface properties were analyzed using contact angle and water vapor permeability techniques. Drug release tests and cell viability assays were performed to evaluate the potential toxicity of the material. SEM images demonstrated that the obtained fibers had nanoscale- and micrometer-scale diameters in PLGA and PMMA systems, respectively. The contact angle analyses indicated that, even in the presence of hydrophilic molecules (SDS and HPβCD), PMMA fibers exhibited hydrophobic characteristics, while PLGA fibers exhibited hydrophilic surface properties. These data were also confirmed by water vapor permeability analysis. The drug release profiles demonstrated a greater release of SDS in the PLGA system. Moreover, the presence of HPβCD improved the drug release in both polymeric systems and the cell viability in the PMMA SDS/HPβCD system. In terms of antibacterial activity, all membranes yielded positive outcomes; nevertheless, the PLGA SDS/HPβCD membrane exhibited the most remarkable results, with the lowest microbial load values. Additionally, the pseudo wound healing analysis demonstrated that the PLGA SDS/HPβCD fiber exhibited results similar to the control group. Consequently, these findings exemplify the substantial potential of the obtained materials for use in wound healing applications.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionLaboratório de Sistemas Poliméricos e Supramoleculares (LSPS) Instituto de Física e Química Universidade Federal de Itajubá (UNIFEI), MG-
Descrição: dc.descriptionLaboratório de Biopolímeros e Biomateriais Universidade de Araraquara (UNIARA), SP-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionNúcleo de Espectroscopia E Estrutura Molecular Departamento de Química—ICE Universidade Federal de Juiz de Fora (UFJF), MG-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 309614/2021-0-
Descrição: dc.descriptionFAPEMIG: APQ-00210-21-
Descrição: dc.descriptionFAPEMIG: APQ-04537-22-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdrug delivery-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectin vitro-
Palavras-chave: dc.subjectnanomaterials-
Palavras-chave: dc.subjectsupramolecular systems-
Título: dc.titleCombining Polymer and Cyclodextrin Strategy for Drug Release of Sulfadiazine from Electrospun Fibers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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