Expression of luteinizing hormone receptor during development of bovine fetal ovary

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Autor(es): dc.contributorUniversidade do Oeste Paulista-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGiroto, Alan Brunholi-
Autor(es): dc.creatorChaves, Marina Platzeck-
Autor(es): dc.creatordos Santos, Priscila Helena-
Autor(es): dc.creatorFontes, Patrícia Kubo-
Autor(es): dc.creatorNunes, Sarah Gomes-
Autor(es): dc.creatorManssur, Thainá Sallum Bacco-
Autor(es): dc.creatorMendes, Leonardo Oliveira-
Autor(es): dc.creatorde Souza Castilho, Anthony César-
Data de aceite: dc.date.accessioned2025-08-21T18:33:51Z-
Data de disponibilização: dc.date.available2025-08-21T18:33:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1984-3143-AR2023-0112-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309838-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309838-
Descrição: dc.descriptionSteroids and gonadotrophins are essential for the regulation of late stages of preantral development and antral follicular development. Although the luteinizing hormone receptor (LHCGR) has been detected in the preantral follicles of rats, rabbits, and pigs, its expression, in bovine fetal ovary, has not been demonstrated. Based on this, we aimed to investigate the expression of the LHCGR and LHCGR mRNA binding protein (LRBP), as well as, to quantify bta-miR-222 (a regulatory microRNA of the LHCGR gene) during the development of bovine fetal ovary. In summary, LHCGR expression was observed in the preantral follicle in bovine fetal ovary, from oogonias to primordial, primary and secondary stages, and the mRNA abundance was lower on day 150 than day 60. However, the mRNA abundance of LRBP followed the opposite pattern. Similar to LRBP, the abundance of bta-miR-222 was higher on day 150 than day 60 or 90 of gestation. The LHCGR protein was detected in oogonia, primordial, primary, and secondary follicles. Moreover, both oocytes and granulosa cells showed positive immunostaining for LHCGR. In conclusion, we suggest the involvement of LHCGRLRBPbta-mir222 with mechanisms related to the development of preantral follicles in cattle.-
Descrição: dc.descriptionUniversidade do Oeste Paulista, SP-
Descrição: dc.descriptionDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, SP-
Descrição: dc.descriptionDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, SP-
Idioma: dc.languageen-
Relação: dc.relationAnimal Reproduction-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLHCGR-
Palavras-chave: dc.subjectmicroRNAs-
Palavras-chave: dc.subjectpreantral follicle-
Palavras-chave: dc.subjectsteroidogenesis-
Título: dc.titleExpression of luteinizing hormone receptor during development of bovine fetal ovary-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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