Control of fluid intake in dehydrated rats and evolution of sodium appetite

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMuséum National d'Histoire Naturelle-
Autor(es): dc.creatorDe Luca, Laurival A.-
Autor(es): dc.creatorLaurin, Michel-
Autor(es): dc.creatorMenani, José Vanderlei-
Data de aceite: dc.date.accessioned2025-08-21T16:58:14Z-
Data de disponibilização: dc.date.available2025-08-21T16:58:14Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2024.114642-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309788-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309788-
Descrição: dc.descriptionThe objective of the present work is to examine from a new perspective the existence of causal factors not predicted by the classical theory that thirst and sodium appetite are two distinct motivations. For example, we ask why water deprivation induces sodium appetite, thirst is not “water appetite”, and intracellular dehydration potentially causes sodium appetite. Contrary to the classical theory, we suggest that thirst first, and sodium appetite second, designate a temporal sequence underlying the same motivation. The single motivation becomes an “intervenient variable” a concept borrowed from the literature, fully explained in the text, between causes of dehydration (extracellular, intracellular, or both together), and respective behavioral responses subserved by hindbrain-dependent inhibition (e.g., lateral parabrachial nucleus) and forebrain facilitation (e.g., angiotensin II). A corollary is homology between rat sodium appetite and marine teleost thirst-like motivation that we name “protodipsia”. The homology argument rests on similarities between behavior (salty water intake) and respective neuroanatomical as well as functional mechanisms. Tetrapod origin in a marine environment provides additional support for the homology. The single motivation hypothesis is also consistent with ingestive behaviors in nature given similarities (e.g., thirst producing brackish water intake) between the behavior of the laboratory rat and wild animals, rodents included. The hypotheses of single motivation and homology might explain why hyperosmotic rats, or eventually any other hyperosmotic tetrapod, shows paradoxical signs of sodium appetite. They might also explain how ingestive behaviors determined by dehydration and subserved by hindbrain inhibitory mechanisms contributed to tetrapod transition from sea to land.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physiology & Pathology School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCR2P UMR 7207 CNRS/MNHN/SU Muséum National d'Histoire Naturelle, Bâtiment de Géologie, CP 48, F-75231 Paris cedex 05-
Descrição: dc.descriptionDepartment of Physiology & Pathology School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: FAPESP-PRONEX-2011/50770–1-
Idioma: dc.languageen-
Relação: dc.relationPhysiology and Behavior-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiotensin-
Palavras-chave: dc.subjectHindbrain-
Palavras-chave: dc.subjectMotivation-
Palavras-chave: dc.subjectTeleost-
Palavras-chave: dc.subjectThirst-
Palavras-chave: dc.subjectTransitional environment-
Título: dc.titleControl of fluid intake in dehydrated rats and evolution of sodium appetite-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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