Anti-Candida activity and biocompatibility of silver nanoparticles associated with denture glaze: a new approach to the management of denture stomatitis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAlmeida, Nara Lígia Martins-
Autor(es): dc.creatorPeralta, Laura Catalí Ferreira-
Autor(es): dc.creatorPontes, Fenelon Martinho Lima-
Autor(es): dc.creatorRinaldo, Daniel-
Autor(es): dc.creatorPorto, Vinicius Carvalho-
Autor(es): dc.creatorLara, Vanessa Soares-
Data de aceite: dc.date.accessioned2025-08-21T22:20:18Z-
Data de disponibilização: dc.date.available2025-08-21T22:20:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12223-024-01161-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309751-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309751-
Descrição: dc.descriptionThe association of silver nanoparticles (AgNps) to sealant agent Palaseal® can be a promising alternative for complete denture wearers who may develop denture stomatitis (DS). The study aimed to evaluate the anti-Candida and biocompatible potential of silver nanoparticles synthesized by three routes associated with denture glaze to prevent and/or treat oral candidiasis. Surface acrylic resin specimens were treated with different associations of glaze with AgNps (VER+AgUV, VER+AgTurk and VER+AgGm). As controls, specimens were treated with glaze+nystatin (VER+Nyst), glaze only (VER) or submerged in PBS (PBS). Afterwards, Candida albicans biofilm was developed for 24 h, 15 d and 30 d. Subsequently, the biofilm was quantified by CFU/mL, XTT assay and confocal laser scanning microscopy. Fibroblasts were submitted to conditioned medium with the same associations for 24, 48 and 72 h and LIVE/DEAD® viability test was carried out. Regardless of the period, there was a significant reduction (p < 0.01) of viable fungal cells load, as well as inhibition of fungal metabolic activity, in specimens treated with glaze+AgNps associations, compared to VER and PBS. The anti-Candida effects of the associations were similar to the VER+Nyst group, with emphasis on VER+AgGm, which showed the highest percentage values of non-viable fungal cells maintained over time. The associations did not prove toxicity to fibroblasts. The AgNps exerted antimicrobial activity against C. albicans biofilms and are biocompatible. The most effective results were achieved with the association of glaze+silver nanoparticles synthesized by the green chemistry method (AgGm), proving to be an innovative alternative in the management of DS.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics Bauru School of Dentistry University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 312182/2021-0-
Formato: dc.format1229-1246-
Idioma: dc.languageen-
Relação: dc.relationFolia Microbiologica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectSilver nanoparticles-
Palavras-chave: dc.subjectStomatitis under denture-
Palavras-chave: dc.subjectSurface sealant agent-
Título: dc.titleAnti-Candida activity and biocompatibility of silver nanoparticles associated with denture glaze: a new approach to the management of denture stomatitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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