Microbiological control of adapted liquid dosage forms in a pediatric hospital from Manaus

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Fed Amazonas-
Autor(es): dc.creatorTashiro, Felipe Mota-
Autor(es): dc.creatorCarvalho, Adriana da Silva-
Autor(es): dc.creatorMagalhaes, Igor Rafael dos Santos-
Autor(es): dc.creatorMagalhaes, Karen Regina Carim da Costa-
Data de aceite: dc.date.accessioned2025-08-21T20:52:36Z-
Data de disponibilização: dc.date.available2025-08-21T20:52:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.17058/reci.v14i3.19484-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309718-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309718-
Descrição: dc.descriptionBackground and Objectives: Ideal dosage forms for pediatric use are liquid because this population has difficulty swallowing. However, the pharmaceutical market does not have a large arsenal. To solve this situation, it is necessary to adapt drugs intended for the adult public in the form of oral solutions that allow the use of pediatric patients. Such practice changes the physicochemical and microbiological properties of these drugs. Most studies on pharmaceutical adaptations are directed to the physicochemical stability. Therefore, this study aimed to perform microbiological control of liquid pharmaceutical forms adapted in a pediatric hospital. Methods: Microbiological analysis was performed according to the specifications of the Brazilian Pharmacopoeia for non-sterile products. The total number of mesophilic microorganisms and the presence of pathogenic microorganisms were counted. Results: During the study period, 36 pharmaceutical adaptations were prepared in the hospital and then, after applying exclusion criteria, 16 samples were selected for microbiological analysis. The most common classes were diuretics, antihypertensives and psycholeptics. No preservatives were used in the preparation of the analyzed pharmaceutical adaptations. Half of the adaptations had a total number of mesophilic microorganisms above the allowed limit on the day of manipulation, 43.75% in the middle of the shelf life and 62.5% in the end of the shelf life. Conclusion: Only 03 (18.75%) adaptations were within the acceptable microbial limits established throughout the study. Regarding the presence of pathogens, all were free from the pathogens Escherichia coli, Salmonella sp., Pseudomonas aeruginosa and Staphylococcus aureus during the study period.-
Descrição: dc.descriptionAmazonas State Research Foundation (FAPEAM) -Amazonas, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Campus Araraquara, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Amazonas, Fac Ciencias Farmaceut, Manaus, AM, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Campus Araraquara, Araraquara, SP, Brazil-
Formato: dc.format441-447-
Idioma: dc.languageen-
Publicador: dc.publisherUniv Santa Cruz Do Sul-
Relação: dc.relationRevista De Epidemiologia E Controle De Infeccao-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBrazilian Pharmacopeia-
Palavras-chave: dc.subjectPediatric Hospitals-
Palavras-chave: dc.subjectPharmaceutical Preparations-
Título: dc.titleMicrobiological control of adapted liquid dosage forms in a pediatric hospital from Manaus-
Tipo de arquivo: dc.typelivro digital-
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