A Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Minho-
Autor(es): dc.contributorLABBELS–Associate Laboratory-
Autor(es): dc.contributorFaculty of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNordi, Tiago Matheus-
Autor(es): dc.creatorGounella, Rodrigo-
Autor(es): dc.creatorAmorim, Marcio L. M.-
Autor(es): dc.creatorLuppe, Maximiliam-
Autor(es): dc.creatorJunior, João Navarro Soares-
Autor(es): dc.creatorAfonso, Joao L.-
Autor(es): dc.creatorMonteiro, Vitor-
Autor(es): dc.creatorAfonso, Jose A.-
Autor(es): dc.creatorTalamoni Fonoff, Erich-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorCarmo, João Paulo-
Data de aceite: dc.date.accessioned2025-08-21T19:59:15Z-
Data de disponibilização: dc.date.available2025-08-21T19:59:15Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jlpea14020028-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309710-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309710-
Descrição: dc.descriptionDeep-brain stimulation (DBS) is a highly effective and safe medical treatment that improves the lives of patients with a wide range of neurological and psychiatric diseases. It has been established as a first-line tool in the treatment of these conditions for the past two decades. Closed-loop deep-brain stimulation (CLDBS) advances this tool further by automatically adjusting the stimulation parameters in real time based on the brain’s response. In this context, this paper presents a low-noise amplifier (LNA) and a neurostimulator circuit fabricated using the low-power/low-voltage 65 nm CMOS process from TSMC. The circuits are specifically designed for implantable applications. To achieve the best tradeoff between input-referred noise and power consumption, metaheuristic algorithms were employed to determine and optimize the dimensions of the LNA devices during the design phase. Measurement results showed that the LNA had a gain of 41.2 dB; a 3 dB bandwidth spanning over three decades, from 1.5 Hz to 11.5 kHz; a power consumption of 5.9 µW; and an input-referred noise of 3.45 µVRMS, from 200 Hz to 11.5 kHz. The neurostimulator circuit is a programmable Howland current pump. Measurements have shown its capability to generate currents with arbitrary shapes and ranging from −325 µA to +318 µA. Simulations indicated a quiescent power consumption of 0.13 µW, with zero neurostimulation current. Both the LNA and the neurostimulator circuits are supplied with a 1.2 V voltage and occupy a microdevice area of 145 µm × 311 µm and 88 µm × 89 µm, respectively, making them suitable for implantation in applications involving closed-loop deep-brain stimulation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGroup of Metamaterials Microwaves and Optics (GMeta) Department of Electrical Engineering (SEL) University of São Paulo (USP) Avenida Trabalhador São-Carlense, Nr. 400, Parque Industrial Arnold Schimidt, São Carlos, SP-
Descrição: dc.descriptionALGORITMI Research Centre/LASI University of Minho-
Descrição: dc.descriptionCMEMS-UMinho University of Minho-
Descrição: dc.descriptionLABBELS–Associate Laboratory-
Descrição: dc.descriptionDepartment of Neurology Faculty of Medicine, Avenida Dr. Arnaldo, Nr. 455, Cerqueira César, São Paulo, SP-
Descrição: dc.descriptionDepartment of Physiology and Pathology Faculty of Odonthology São Paulo State University (UNESP), Rua Humaitá, Nr. 1680, SP-
Descrição: dc.descriptionDepartment of Physiology and Pathology Faculty of Odonthology São Paulo State University (UNESP), Rua Humaitá, Nr. 1680, SP-
Descrição: dc.descriptionCNPq: 402752/2023-6-
Idioma: dc.languageen-
Relação: dc.relationJournal of Low Power Electronics and Applications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectclosed-loop deep-brain stimulation-
Palavras-chave: dc.subjectimplantable devices-
Palavras-chave: dc.subjectlow-noise amplifier-
Palavras-chave: dc.subjectneurostimulation-
Título: dc.titleA Microdevice in a Submicron CMOS for Closed-Loop Deep-Brain Stimulation (CLDBS)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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