Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorHospital Infantil Albert Sabin-
Autor(es): dc.contributorHospital da Criança de Brasília Jose Alencar-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorPedro Ernesto University Hospital-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericórdia de São Paulo-
Autor(es): dc.contributorJoão Pessoa-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorHospital Evangélico de Curitiba-
Autor(es): dc.contributorHospital Criança Conceição-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorTrindade, Vitor C-
Autor(es): dc.creatorBonfá, Eloisa-
Autor(es): dc.creatorSakamoto, Ana P-
Autor(es): dc.creatorTerreri, Maria T-
Autor(es): dc.creatorAikawa, Nádia E-
Autor(es): dc.creatorFiorot, Fernanda J-
Autor(es): dc.creatorPitta, Ana C-
Autor(es): dc.creatorBalbi, Verena A-
Autor(es): dc.creatorN Rabelo, Carlos-
Autor(es): dc.creatorSilva, Marco F-
Autor(es): dc.creatorIslabão, Aline G-
Autor(es): dc.creatorNovak, Glaucia V-
Autor(es): dc.creatorKozu, Katia T-
Autor(es): dc.creatorBuscatti, Izabel M-
Autor(es): dc.creatorCampos, Lucia M-
Autor(es): dc.creatorSallum, Adriana ME-
Autor(es): dc.creatorAssad, Ana P-
Autor(es): dc.creatorMagalhães, Claudia S-
Autor(es): dc.creatorMarini, Roberto-
Autor(es): dc.creatorFonseca, Adriana R-
Autor(es): dc.creatorSztajnbok, Flavio R-
Autor(es): dc.creatorSantos, Maria C-
Autor(es): dc.creatorBica, Blanca E-
Autor(es): dc.creatorSena, Evaldo G-
Autor(es): dc.creatorMoraes, Ana J-
Autor(es): dc.creatorRobazzi, Teresa C-
Autor(es): dc.creatorSpelling, Paulo F-
Autor(es): dc.creatorScheibel, Iloite M-
Autor(es): dc.creatorCavalcanti, Andre S-
Autor(es): dc.creatorMatos, Erica N-
Autor(es): dc.creatorGuimarães, Luciano J-
Autor(es): dc.creatorSantos, Flavia P-
Autor(es): dc.creatorCarvalho, Luciana M-
Autor(es): dc.creatorCarneiro-Sampaio, Magda-
Autor(es): dc.creatorFerraro, Alexandre A-
Autor(es): dc.creatorSilva, Clovis A-
Data de aceite: dc.date.accessioned2025-08-21T19:54:44Z-
Data de disponibilização: dc.date.available2025-08-21T19:54:44Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/09612033251317357-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309673-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309673-
Descrição: dc.descriptionObjective: To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody clusters and the following variables: demographic data, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality. Methods: A cross-sectional study was performed in 27 Pediatric Rheumatology University centers, including 912 cSLE patients. The frequencies of seven selected autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) were used for cluster analysis using the K-means method. Results: Four distinctive antibody clusters were identified. Cluster 1 (n = 322; 35.31%) was characterized by anti-dsDNA (61.18%), low frequency of antiphospholipid antibodies (<10%), and lower frequency of cutaneous, articular manifestation (p < 0.05) and hypocomplementemia (p < 0.001) compared to the other groups. Cluster 2 (n = 158; 17.32%) comprised anti-dsDNA (93.04%), aCL (87.34%) and LA (39.87%) and higher frequencies of thrombocytopenia (p = 0.006) and antiphospholipid syndrome (p < 0.001) than the other clusters. Cluster 3 (n = 177; 19.41%) was characterized by anti-dsDNA (81.36%), anti-Sm (100%) and anti-RNP (44.63%) antibodies, as well as a higher frequency of proteinuria compared to cluster 4 (58.15% vs 56.13% vs 64.00% vs 49.80%, p = 0.031). Cluster 4 (n = 255; 27.96%) consisted of all 7 autoantibodies, with predominance of anti-dsDNA (72.55%), anti-Ro/SSA (89.8%) and anti-La/SSB (45.88%), with no specific clinical pattern, except by higher pulmonary damage (p = 0.017). Conclusions:Our study suggests that, within the context of cSLE, the coexistence of anti-dsDNA with antiphospholipid autoantibodies is linked to an elevated incidence of antiphospholipid syndrome. This association does not coincide with a proportionate increase in the occurrence of nephritis. Conversely, the cluster of anti-dsDNA with anti-Ro/SSA and anti-La/SSB antibodies was associated with pulmonary damage, requiring close surveillance.-
Descrição: dc.descriptionPediatric Rheumatology Unit Instituto da Criança e do Adolescente Hospital das Clínicas HCFMUSP-
Descrição: dc.descriptionFaculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionDivision of Rheumatology Hospital das Clínicas HCFMUSP-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal de São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Infantil Albert Sabin-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital da Criança de Brasília Jose Alencar-
Descrição: dc.descriptionPediatric Rheumatology Unit Sao Paulo State University (UNESP)-
Descrição: dc.descriptionPediatric Rheumatology Unit University of Campinas (UNICAMP)-
Descrição: dc.descriptionPediatric Rheumatology Unit Rio de Janeiro Federal University (IPPMG-UFRJ)-
Descrição: dc.descriptionPediatric Rheumatology Unit Pedro Ernesto University Hospital-
Descrição: dc.descriptionPediatric Rheumatology Unit Irmandade da Santa Casa de Misericórdia de São Paulo-
Descrição: dc.descriptionRheumatology Division Universidade Federal do Rio de Janeiro-
Descrição: dc.descriptionPediatric Rheumatology Unit Lauro Wanderley University Hospital João Pessoa-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Pará-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Bahia-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Evangélico de Curitiba-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Criança Conceição-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Pernambuco-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionPediatric Rheumatology Unit University of Brasília-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Minas Gerais-
Descrição: dc.descriptionPediatric Rheumatology Unit Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationLupus-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantiphospholipid syndrome-
Palavras-chave: dc.subjectautoantibody-
Palavras-chave: dc.subjectChildhood-onset systemic lupus erythematosus-
Palavras-chave: dc.subjectcluster analysis-
Palavras-chave: dc.subjectpulmonary damage-
Título: dc.titleAutoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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