Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Santiago de Compostela-
Autor(es): dc.contributorComplutense University-
Autor(es): dc.contributorUniversity of Crete-
Autor(es): dc.contributorNational University of Cuyo-
Autor(es): dc.contributorNational Council for Scientific and Technological Research (CONICET)-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorAlmeida Chuffa, Luiz Gustavo De-
Autor(es): dc.creatorSimão, Vinícius Augusto-
Autor(es): dc.creatorGiménez, Virna Margarita Martín-
Autor(es): dc.creatorHeras, Natalia De Las-
Autor(es): dc.creatorSpandidos, Demetrios A.-
Autor(es): dc.creatorManucha, Walter-
Data de aceite: dc.date.accessioned2025-08-21T17:56:18Z-
Data de disponibilização: dc.date.available2025-08-21T17:56:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3892/ijo.2024.5702-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309604-
Descrição: dc.descriptionSignificant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute to deficien‑ cies in melatonin and vitamin D. Limited sun exposure affects vitamin D synthesis, and artificial light at night suppresses melatonin production. Both melatonin and vitamin D possess anti‑inflammatory, immune‑boosting and anticancer proper‑ ties, rendering them potential adjuvants of interest. Studies suggest melatonin and vitamin D supplementation may address antioxidant imbalances in lip, oral and pharyngeal cancers. Moreover, promising results from breast, head and neck, brain, and osteosarcoma research indicate potential for tumor growth inhibition, improved survival, and a better quality of life of patients with cancer. The radioprotective properties of melatonin and vitamin D are another exciting area of explora‑ tion, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, the sleep‑promoting effects of melatonin may indirectly benefit patients with cancer by influencing the immune system. Thus, the prevalence of vitamin D and melatonin deficiencies highlights the importance of supplementation, as lower levels can worsen side‑effects from cancer treatments. The present review explores the potential of combining melatonin and vitamin D as synergistic adjuvants for cancer therapy. These agents have shown promise individu‑ ally in cancer prevention and treatment, and their combined effects warrant investigation. Therefore, large‑scale controlled trials are crucial to definitively determine the optimal dosage, safety and efficacy of this combination in improving the lives of patients with cancer.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionMinisterio de Ciencia e Innovación-
Descrição: dc.descriptionDepartment of Cellular and Structural Biology UT Health-
Descrição: dc.descriptionDepartment of Structural and Functional Biology UNESP São Paulo State University Institute of Bio‑sciences, Botucatu, CEP-
Descrição: dc.descriptionCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS) University of Santiago de Compostela-
Descrição: dc.descriptionDepartment of Physiology Faculty of Medicine Complutense University-
Descrição: dc.descriptionLaboratory of Clinical Virology School of Medicine University of Crete-
Descrição: dc.descriptionDepartment of Pathology Faculty of Medical Sciences National University of Cuyo-
Descrição: dc.descriptionInstitute of Medicine Experimental Biology of Cuyo (IMBECU) National Council for Scientific and Technological Research (CONICET)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology UNESP São Paulo State University Institute of Bio‑sciences, Botucatu, CEP-
Descrição: dc.descriptionMinisterio de Ciencia e Innovación: PID2021‑1230760B‑100-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectmelatonin-
Palavras-chave: dc.subjectsynergistic actions-
Palavras-chave: dc.subjecttreatment-
Palavras-chave: dc.subjectvitamin D-
Título: dc.titleMelatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.