Single-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRegina da Silva Correa da Ronda, Carla-
Autor(es): dc.creatorBerlofa Visacri, Marília-
Autor(es): dc.creatorTiemi Siguemoto, Júlia-
Autor(es): dc.creatorMotta Neri, Carolini-
Autor(es): dc.creatorCrispim Lopo de Abreu, Micaela-
Autor(es): dc.creatorde Souza Nicoletti, Aline-
Autor(es): dc.creatorRotta, Inajara-
Autor(es): dc.creatorDagli-Hernandez, Carolina-
Autor(es): dc.creatorMoriel Pincinato, Pedro-
Autor(es): dc.creatorde Carvalho Pincinato, Eder-
Autor(es): dc.creatorMoriel, Patricia-
Data de aceite: dc.date.accessioned2025-08-21T18:31:22Z-
Data de disponibilização: dc.date.available2025-08-21T18:31:22Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.gene.2024.148236-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309562-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309562-
Descrição: dc.descriptionThis systematic review and meta-analysis aimed to verify the association between single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and the severity or mortality of coronavirus disease 19 (COVID-19). We systematically searched PubMed, BVS/Bireme, Scopus, Embase, and Web of Science for relevant studies published until November 24, 2023. Twelve studies were included. Thirty-one SNPs related to four genes were studied (VDR, 13 SNPs; GC, 6 SNPs; DHCR7/NADSYN1, 6 SNPs; CYP2R1, 6 SNPs). Eight SNPs were examined in two or more studies (VDR rs731236, rs2228570, rs1544410, rs7975232, rs739837, rs757343, rs11568820, and rs4516035). Meta-analysis showed a significant association between the VDR rs1544410 Bb + bb genotype and b allele and an increased odds of developing severe/critical COVID-19 (Bb + bb vs. BB = 2 studies, OR = 1.73, 95% confidence interval (CI): 1.16–2.57, P = 0.007, I2 = 0%; b allele vs. B allele = 2 studies, OR = 1.31, 95% CI: 1.03–1.67; P = 0.03; I2 = 0%). Regarding the mortality rate, VDR rs731236 TT-genotype, TT + Tt genotype, and T allele; VDR rs1544410 bb-genotype, Bb + bb genotype, and b allele; VDR rs7975232 AA-genotype, AA + Aa genotype, and A allele; and VDR rs2228570 ff-genotype, Ff + ff genotype, and f allele were associated with increased odds of death due to COVID-19. In conclusion, the present study suggests that SNPs rs1544410 may serve as a predictive biomarker for COVID-19 severity and rs731236, rs1544410, rs7975232, and rs2228570 as predictive biomarkers for COVID-19 mortality. More well-designed studies involving a larger number of COVID-19 patients are required to validate and replicate these findings.-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) Faculty of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionUniversity of São Paulo (USP) Faculty of Pharmaceutical Sciences Department of Pharmacy, SP-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) School of Medical Sciences Department of Pharmacology, SP-
Descrição: dc.descriptionFederal University of Paraná (UFPR) Department of Pharmacy, PR-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agriculture, SP-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) School of Medical Sciences Department of Clinical Pathology, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agriculture, SP-
Idioma: dc.languageen-
Relação: dc.relationGene-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCritical Illness-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectSingle nucleotide polymorphism-
Palavras-chave: dc.subjectVDR protein-
Título: dc.titleSingle-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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