The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorReproductive Medicine Centre-
Autor(es): dc.contributorClinica EUGIN-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Nottingham-
Autor(es): dc.contributorFondazione IRCCS San Gerardo dei Tintori Monza-
Autor(es): dc.creatorBuratini, Jose-
Autor(es): dc.creatorMoutier, Clarissa-
Autor(es): dc.creatorGuglielmo, Maria Cristina-
Autor(es): dc.creatorTurchi, Diana-
Autor(es): dc.creatorWebb, Robert-
Autor(es): dc.creatorDe Ponti, Elena-
Autor(es): dc.creatorRenzini, Mario Mignini-
Autor(es): dc.creatorCanto, Mariabeatrice Dal-
Data de aceite: dc.date.accessioned2025-08-21T17:42:58Z-
Data de disponibilização: dc.date.available2025-08-21T17:42:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10815-023-02895-9-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309551-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309551-
Descrição: dc.descriptionPurpose: To assess the effects of oocyte central granularity and its underlying endocrine environment on developmental competence of dysmorphic and morphologically normal oocytes. Methods: Retrospective cohort study including 1,082 patients undergoing autologous ICSI cycles. Of these, 211 patients provided 602 oocytes with central granularity (CG) and 427 morphologically normal cycle companion oocytes (NCG). The remaining 871 patients provided only morphologically normal oocytes in cycles not yielding dysmorphic oocytes (N). Patient profile associated with CG was characterized, and fertilization rates, early morphokinetics and live birth rates were compared between N, CG and NCG groups. Patient characteristics associated with implantation and delivery performance of CG-derived embryos were assessed. Results: CG was associated with higher maternal age, basal FSH concentrations and total FSH dose, but with lower circulating AMH (p ≤ 0.035). Fertilization rates were reduced and early morphokinetic parameters were delayed in CG (p < 0.025) and NCG (p < 0.05) groups as compared to the N group. Embryos derived from CG oocytes achieved a markedly lower live birth rate (14.9%) as compared to those derived from NCG (36.8%; p = 0.03) and N oocytes (29.8%; p = 0.002). The negative relationship between CG and live birth was confirmed by a multivariate analysis controlling for potential confounders (OR:2.59, IC:1.27–5.31; P = 0.009). Implantation and delivery rates following transfers of CG-derived embryos were inversely associated with maternal age. Conclusion: CG oocytes, but not their morphologically normal cycle companions, have severely compromised developmental competence. Maternal age should be a key parameter in deciding whether or not to utilize CG oocytes in ICSI cycles.-
Descrição: dc.descriptionBiogenesi Reproductive Medicine Centre-
Descrição: dc.descriptionClinica EUGIN-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionUniversity of Nottingham-
Descrição: dc.descriptionMedical Physics Fondazione IRCCS San Gerardo dei Tintori Monza-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University, SP-
Formato: dc.format2375-2384-
Idioma: dc.languageen-
Relação: dc.relationJournal of Assisted Reproduction and Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFertilization-
Palavras-chave: dc.subjectLive birth-
Palavras-chave: dc.subjectMaternal age-
Palavras-chave: dc.subjectMorphokinetics-
Palavras-chave: dc.subjectOocyte central granularity-
Título: dc.titleThe impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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