Complications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorIanhez, Mayra-
Autor(es): dc.creatorde Goés e Silva Freire, Giselle-
Autor(es): dc.creatorSigrist, Rosa Maria Silveira-
Autor(es): dc.creatorColpas, Paula Tavares-
Autor(es): dc.creatorde Faria, Isabella Alves-
Autor(es): dc.creatorParada, Meire Odete Américo Brasil-
Autor(es): dc.creatorMiot, Hélio Amante-
Data de aceite: dc.date.accessioned2025-08-21T17:29:57Z-
Data de disponibilização: dc.date.available2025-08-21T17:29:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jocd.16343-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309544-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309544-
Descrição: dc.descriptionBackground: Complications of temporary and permanent fillers have been extensively studied. However, there is a lack of comparative data regarding poly-L-lactic acid (PLLA), calcium hydroxyapatite (CaHA), and polycaprolactone (PCL) known as collagen biostimulators. Aims: This study addressed the complications of collagen biostimulators concerning their diagnosis, type of product, treatment, and monitoring. Patients/Methods: An electronic questionnaire was sent to Brazilian dermatologic ultrasound experts to identify complications related to biostimulators. The type of biostimulator, location of application, number of vials injected, application plan, time between injection treatment and complication, injector profile, treatment, and prognosis were assessed. Results: Fifty-five cases were identified, of which 49.1% were caused by PLLA-Elleva®, 23.6% by CaHA (alone or combined with hyaluronic acid), 20.0% by PLLA-Sculptra®, and 7.3% by PCL. The most affected area was the face (72.7%), with nodules being the most common clinical form (89.1%), generally occurring late (60.0%) (>1 month). Only one case was injected at an incorrect depth (musculoaponeurotic system—SMAS). Despite several treatments, including saline (45.5%), hyaluronidase (25.5%), diluted corticosteroids (23.6%), and energy-based devices (10.9%), only five cases showed complete resolution. Hyaluronidase was beneficial in complications related to fillers when there was an association of calcium hydroxyapatite with hyaluronic acid (p < 0.01). Conclusions: Complications from collagen biostimulators were more common on the face, typically manifesting about 1 month after treatment. These issues seemed to be related more to the properties of the products rather than inadequate technique. Furthermore, hyaluronidase demonstrated efficacy only in cases where there was an association with HA.-
Descrição: dc.descriptionUniversidade Federal de Goiás-
Descrição: dc.descriptionInstituto de Radiologia da Faculdade de Medicina da USP-
Descrição: dc.descriptionPontifícia Universidade de Campinas-
Descrição: dc.descriptionUniversidade Federal de São Paulo – UNIFESP-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Formato: dc.format2829-2835-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cosmetic Dermatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcalcium hydroxyapatite-
Palavras-chave: dc.subjectcomplications-
Palavras-chave: dc.subjectdermal fillers-
Palavras-chave: dc.subjectnodules-
Palavras-chave: dc.subjectpoly-L-lactic acid-
Título: dc.titleComplications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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