The role of a local application of 10% doxycycline gel in the prevention of medication-related osteonecrosis of the jaw in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorHarvard School of Dental Medicine-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorde Jesus, Laís Kawamata-
Autor(es): dc.creatorPereira-Silva, Maísa-
Autor(es): dc.creatorOliveira, Maria Eduarda de Freitas Santana-
Autor(es): dc.creatorMonteiro, Naara Gabriela-
Autor(es): dc.creatorPoli, Pier Paolo-
Autor(es): dc.creatorMaiorana, Carlo-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorGuastaldi, Fernando Pozzi Semeghini-
Autor(es): dc.creatorde Almeida, Juliano Milanezi-
Autor(es): dc.creatorSouza, Francisley Ávila-
Data de aceite: dc.date.accessioned2025-08-21T17:22:30Z-
Data de disponibilização: dc.date.available2025-08-21T17:22:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-025-06279-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309535-
Descrição: dc.descriptionObjectives: This study aimed to evaluate doxycycline on the prevention of MRONJ. Materials and methods: Seventy-two Wistar rats were sorted into 3 groups and subjected to tooth extractions. The first group received systemic saline solution (SAL), the second received zoledronic acid (ZA), and the third, besides the systemic ZA, the post-extraction socket received local application of doxycycline (DOXI) gel. Samples were collected and analyzed at 7, 14, and 28 postoperative days. Results: DOXI group presented higher percentage of vital bone area as compared with ZA at 7 (p = 0.0058), 14 (p < 0.0001), and 28 days (p < 0.0001). TRAP immunolabeling was lower in ZA and DOXI at 7 and 14 days, while OCN immunolabeling was similar between the ZA and DOXI, except at 7 days. At 14 and 28 days, DOXI group presented more collagen type 3 and 1 (p < 0.0001) as compared with ZA. RUNX2, ALP, OCN, and RANKL gene expression was downregulated in ZA at 7 days. Conversely, DOXI upregulated these markers and OPG over time (p < 0.05). Conclusion: Doxycycline is an effective local agent for preventing MRONJ, favoring alveolar bone healing. Clinical relevance. Although widely studied, MRONJ remains a significant challenge in dentistry. The search for preventive methods is important to assure safety for in patients under antiresorptive therapy that demand surgical dental treatment. Doxycycline is well-established in dentistry, and the proposal of using this medication as a gel makes it more appealing since it is applied locally and has negligible adverse effects.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Oral & Maxillofacial Surgery Division School of Dentistry São Paulo State University (UNESP), 1193 José Bonifácio St, SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionImplant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-
Descrição: dc.descriptionDepartment of Biomedical Surgical and Dental Sciences University of Milan-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery Massachusetts General Hospital Harvard School of Dental Medicine-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Periodontics Division School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Oral & Maxillofacial Surgery Division School of Dentistry São Paulo State University (UNESP), 1193 José Bonifácio St, SP-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Periodontics Division School of Dentistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiresorptive drugs-
Palavras-chave: dc.subjectBisphosphonates-
Palavras-chave: dc.subjectBone repair-
Palavras-chave: dc.subjectDoxycycline-
Palavras-chave: dc.subjectMRONJ-
Título: dc.titleThe role of a local application of 10% doxycycline gel in the prevention of medication-related osteonecrosis of the jaw in rats-
Tipo de arquivo: dc.typelivro digital-
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