Alcohol Deprivation Differentially Changes Alcohol Intake in Female and Male Rats Depending on Early-Life Stressful Experience

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Autor(es): dc.contributorState Univ Goias-
Autor(es): dc.contributorGrad Program Sci Appl Hlth Prod PPGCAPS UEG-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCarvalho, Marielly-
Autor(es): dc.creatorMorais-Silva, Gessynger-
Autor(es): dc.creatorBatista Caixeta, Graziele Alicia-
Autor(es): dc.creatorMarin, Marcelo T.-
Autor(es): dc.creatorAmaral, Vanessa C. S.-
Data de aceite: dc.date.accessioned2025-08-21T22:58:28Z-
Data de disponibilização: dc.date.available2025-08-21T22:58:28Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/neurosci3020016-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309510-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309510-
Descrição: dc.descriptionExperiencing early-life adverse events has enduring effects on individual vulnerability to alcohol abuse and the development of addiction-related behaviors. In rodents, it can be studied using maternal separation (MS) stress. Studies have shown that, depending on the protocol used, MS can affect the mother and pups' behavior and are associated with behavioral alterations later in adulthood, associated with both positive or negative outcomes. However, it is not fully elucidated how MS affects relapse-like behaviors when experienced by female or male individuals. Therefore, the aim of our study was to evaluate the effects of brief and prolonged MS on the alcohol deprivation effect (ADE) in female and male rats. Female and male Wistar rats were exposed to brief (15 min/day) or prolonged (180 min/day) MS from postnatal day (PND) 2 to 10. Later, during adulthood (PND 70), animals were submitted to an ADE protocol. Brief MS exposure prevented the ADE in both females and males, while prolonged MS exposure also prevented the ADE in female rats. Moreover, the ADE was more robust in females when compared to males. In conclusion, we showed that male and female rats are differentially affected by alcohol deprivation periods depending on their early-life experiences.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionState Univ Goias, Lab Pharmacol & Toxicol Nat & Synthet Prod, Exact & Technol Sci Campus, BR-75132903 Anapolis, Go, Brazil-
Descrição: dc.descriptionGrad Program Sci Appl Hlth Prod PPGCAPS UEG, BR-75132903 Anapolis, GO, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Lab Pharmacol, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionUNESP, Joint Grad Program Physiol Sci PIPGCF UFSCar, BR-14801903 Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Lab Pharmacol, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionUNESP, Joint Grad Program Physiol Sci PIPGCF UFSCar, BR-14801903 Araraquara, SP, Brazil-
Descrição: dc.descriptionCNPq: 201610267001023-
Formato: dc.format214-225-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationNeurosci-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectaddiction-
Palavras-chave: dc.subjectmaternal separation-
Palavras-chave: dc.subjectrisk factor-
Palavras-chave: dc.subjectsex differences-
Título: dc.titleAlcohol Deprivation Differentially Changes Alcohol Intake in Female and Male Rats Depending on Early-Life Stressful Experience-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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