Aspects related to biofilm production and antifungal susceptibility of clinically relevant yeasts of the genus Trichosporon

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNúcleo de Ciências Biomédicas-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorServiço de Controle de Infecção Hospitalar-
Autor(es): dc.contributorHospital Infantil Darcy Vargas-
Autor(es): dc.contributorHospital Estadual Bauru (HEB)-
Autor(es): dc.contributorCentro de Parasitologia e Micologia-
Autor(es): dc.contributorUniversidade Federal Do Mato Grosso Do Sul-
Autor(es): dc.contributorUniversidade Estadual Do Centro Oeste (UNICENTRO)-
Autor(es): dc.contributorUniversidade Federal de Alfenas (UNIFAL)-
Autor(es): dc.creatorLara, Bruna Rossini-
Autor(es): dc.creatorDe Camargo, Bruno Braidotti-
Autor(es): dc.creatorPaula, Claudete Rodrigues-
Autor(es): dc.creatorDe Morais Monari, Gabrielle Pires-
Autor(es): dc.creatorGarces, Hans Garcia-
Autor(es): dc.creatorArnoni, Mariana Volpe-
Autor(es): dc.creatorSilveira, Mônica-
Autor(es): dc.creatorGimenes, Viviane Mazo Fávero-
Autor(es): dc.creatorLeite Junior, Diniz Pereira-
Autor(es): dc.creatorBonfietti, Lucas Xavier-
Autor(es): dc.creatorOliveira, Lidiane-
Autor(es): dc.creatorDe Souza Carvalho Melhem, Márcia-
Autor(es): dc.creatorAuler, Marcos-
Autor(es): dc.creatorRamos, Regina Teixeira Barbieri-
Autor(es): dc.creatorDias, Amanda Latercia Tranches-
Autor(es): dc.creatorSilva, Naiara Chaves-
Autor(es): dc.creatorMoreira, Débora-
Autor(es): dc.creatorRichini-Pereira, Virgínia Bodelão-
Autor(es): dc.creatorAnversa, Laís-
Autor(es): dc.creatorRuiz, Luciana Da Silva-
Data de aceite: dc.date.accessioned2025-08-21T22:38:57Z-
Data de disponibilização: dc.date.available2025-08-21T22:38:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/mmy/myad022-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309485-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309485-
Descrição: dc.descriptionTrichosporonosis corresponds to a systemic fungal disease that leads to high mort alit y rates and is frequently associated with medical devices. It affects immunosuppressed patients in particular and is strongly linked to acquired human immunodeficiency, organ and tissue transplants, and malignant hematologic diseases such as leukemia and lymphomas. Trichosporon infections have been increasingly reported worldwide; however, little information is available either about their characteristics or the causative microorganism. Thus, the aims of the present study were: to investigate 59 yeasts of the genus Trichosporon by verifying the biofilm formation capacity of isolates; to analyze the susceptibility patterns of planktonic cells against the antifungals fluconazole, itraconazole, amphotericin-B, voriconazole, and caspofungin by comparing European Committee for Antimicrobial Susceptibility Testing (EUCAST) broth microdilution technique with the commercial method Etest; and to assess the susceptibility patterns of biofilm cells (sessile) against the same antifungals through broth microdilution. The ability to form biofilm on the surface of polystyrene plates was noted for all isolates, and 54.3% of samples were considered strong producers. Comparison between the antifungal susceptibility techniques evidenced that Etest showed higher and discordant minimum inhibitory concentrations (MICs) from those obtained by the microdilution method, especially for fluconazole, itraconazole, and caspofungin. Considering the susceptibility of biofilms, most species had high MIC 50 and MIC 90 against the tested antifungals, showing 4-to-66-fold higher concentrations for amphotericin B and 2-to-33-fold greater concentrations for caspofungin. These results highlight the importance of further studies with Trichosporon spp. for comparison between laboratory findings and in vivo response, considering both the susceptibility tests and the behavior of biofilm cells against drugs.-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista (UNESP), São Paulo-
Descrição: dc.descriptionInstituto Adolfo Lutz (IAL) - CLR II Núcleo de Ciências Biomédicas, São Paulo-
Descrição: dc.descriptionFaculdade de Odontologia Universidade de São Paulo (USP), SP-
Descrição: dc.descriptionIrmandade da Santa Casa de Misericórdia de São Paulo Serviço de Controle de Infecção Hospitalar, SP-
Descrição: dc.descriptionHospital Infantil Darcy Vargas, SP-
Descrição: dc.descriptionHospital Estadual Bauru (HEB), SP-
Descrição: dc.descriptionInstituto de Medicina Tropical Universidade de São Paulo (USP), SP-
Descrição: dc.descriptionInstituto Adolfo Lutz (IAL) Central Centro de Parasitologia e Micologia, SP-
Descrição: dc.descriptionPrograma de Pós-Graduação em Doenças Infecciosas Universidade Federal Do Mato Grosso Do Sul, MS-
Descrição: dc.descriptionFaculdade de Farmácia Universidade Estadual Do Centro Oeste (UNICENTRO), PR-
Descrição: dc.descriptionInstituto de Ciências Biomédicas Universidade Federal de Alfenas (UNIFAL), MG-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationMedical Mycology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal susceptibility-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectemerging pathogens-
Palavras-chave: dc.subjecttrichosporon spp-
Título: dc.titleAspects related to biofilm production and antifungal susceptibility of clinically relevant yeasts of the genus Trichosporon-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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