BALB/c and C57BL/6 mouse strains influence gastric function outcomes with administration of cisplatin and dexamethasone

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUFMT-
Autor(es): dc.contributorUNCISAL-
Autor(es): dc.creatorGama, Loyane Almeida-
Autor(es): dc.creatorMachado, Mariana Pirani Rocha-
Autor(es): dc.creatorCorá, Luciana Aparecida-
Autor(es): dc.creatorBeckmann, Ana Paula Simões-
Autor(es): dc.creatorAlves, Wellington David Luz-
Autor(es): dc.creatorMiranda, José Ricardo de Arruda-
Autor(es): dc.creatorAmérico, Madileine Francely-
Data de aceite: dc.date.accessioned2025-08-21T15:10:00Z-
Data de disponibilização: dc.date.available2025-08-21T15:10:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902023e22718-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/309462-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/309462-
Descrição: dc.descriptionOur aim was to evaluate the effects of cisplatin and dexamethasone alone and combined on gastric contractility and histomorphometry of BALB/c and C57BL/6 mice. BALB/c and C57BL/6 male mice (8-week-old) were randomly separated into: Control; Cisplatin (7.5 mg/Kg); Dexamethasone (2.0 mg/Kg); and Dexamethasone plus Cisplatin (2.0 mg/Kg of dexamethasone 1-hour prior to 7.5 mg/Kg of cisplatin). Drugs were administered intraperitoneally for three days. Body weight and food intake were evaluated on 2nd day. Alternating Current Biosusceptometry technique was employed to measure gastric contractions on 3rd day. Afterward, mice were killed for gastric histomorphometric analysis. Cisplatin decreased food intake and caused bradygastria in BALB/c mice; however, the amplitude of gastric contractions decreased in both BALB/c and C57BL/6. Dexamethasone and cisplatin combined restored the gastric frequency and food intake only in BALB/c, but drug combination reduced the gastric amplitude of contractions in both strains. Dexamethasone alone increased gastric mucosa thickness in C57BL/6 and decreased muscular thickness in BALB/c. In conclusion, the mouse strains presented differences in acute effects of cisplatin and dexamethasone alone and combined on gastric function. This reinforces the importance of choosing the appropriate mouse strain for studying the acute effects of drugs on the gastrointestinal tract.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionInstitute of Biological Sciences and Health Federal University of Mato Grosso UFMT, MT-
Descrição: dc.descriptionIntegrative Sciences Center Alagoas State University of Health Sciences UNCISAL, AL-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBALB/c-
Palavras-chave: dc.subjectBradygastria-
Palavras-chave: dc.subjectC57BL/6-
Palavras-chave: dc.subjectGastric motility-
Palavras-chave: dc.subjectStomach-
Título: dc.titleBALB/c and C57BL/6 mouse strains influence gastric function outcomes with administration of cisplatin and dexamethasone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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